[English] 日本語
![](img/lk-miru.gif)
- PDB-2des: INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYS... -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 2des | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Title | INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG) | ||||||||||||||||||
![]() | DNA (5'-D(*![]() DNA / RIGHT HANDED DNA / DOUBLE HELIX / COMPLEXED WITH DRUG | Function / homology | Chem-DMM / DNA | ![]() Method | ![]() ![]() Cirilli, M. / Bachechi, F. / Ughetto, G. / Colonna, F.P. / Capobianco, M.L. | ![]() ![]() Title: Interactions between morpholinyl anthracyclines and DNA. The crystal structure of a morpholino doxorubicin bound to d(CGTACG). Authors: Cirilli, M. / Bachechi, F. / Ughetto, G. / Colonna, F.P. / Capobianco, M.L. #1: ![]() Title: Interactions Between an Anthracycline Antibiotic and DNA: Molecular Structure of Daunomycin Complexed to d(CpGpTpApCpG) at 1.2-Angstroms Resolution Authors: Wang, A.-H.J. / Ughetto, G. / Quigley, G.J. / Rich, A. #2: ![]() Title: Structure of 11-Deoxydaunomycin Bound to DNA Containing a Phosphorothioate Authors: Williams, L.D. / Egli, M. / Ughetto, G. / Van Der Marel, G.A. / Van Boom, J.H. / Quigley, G.J. / Wang, A.H.-J. / Rich, A. / Frederick, C.A. History |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 24.8 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 14.7 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 1 MB | Display | ![]() |
---|---|---|---|---|
Full document | ![]() | 1.1 MB | Display | |
Data in XML | ![]() | 8.4 KB | Display | |
Data in CIF | ![]() | 9.9 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
---|
-
Links
-
Assembly
Deposited unit | ![]()
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||
Unit cell |
|
-
Components
#1: DNA chain | Mass: 1809.217 Da / Num. of mol.: 2 / Source method: obtained synthetically #2: Chemical | #3: Chemical | #4: Chemical | ChemComp-MG / | #5: Water | ChemComp-HOH / | |
---|
-Experimental details
-Experiment
Experiment | Method: ![]() |
---|
-
Sample preparation
Crystal | Density Matthews: 2.45 Å3/Da / Density % sol: 49.82 % | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Crystal grow | Method: vapor diffusion, sitting drop / pH: 5.5 / Details: pH 5.50, VAPOR DIFFUSION, SITTING DROP / Temp details: ROOM TEMPERATURE | ||||||||||||||||||||||||||||||||
Components of the solutions |
| ||||||||||||||||||||||||||||||||
Crystal grow | *PLUS pH: 5.5 / Method: other | ||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
|
-Data collection
Diffraction | Ambient temp details: ROOM TEMPERATURE |
---|---|
Detector | Type: SYNTEX P21 / Detector: DIFFRACTOMETER |
Radiation | Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
Reflection | Num. obs: 3988 |
Reflection | *PLUS |
-
Processing
Software | Name: NUCLSQ / Classification: refinement | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Resolution: 1.5→10 Å / σ(F): 2 /
| ||||||||||||
Refine Biso |
| ||||||||||||
Refinement step | Cycle: LAST / Resolution: 1.5→10 Å
| ||||||||||||
Refinement | *PLUS Highest resolution: 1.5 Å / Lowest resolution: 10 Å / Num. reflection obs: 3588 / Rfactor obs: 0.192 / σ(F): 2 | ||||||||||||
Solvent computation | *PLUS | ||||||||||||
Displacement parameters | *PLUS |