登録情報 | データベース: EMDB / ID: EMD-22812 |
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タイトル | Full-length human mitochondrial Hsp90 (TRAP1) in complex with SdhB in the presence of AMP-PNP |
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マップデータ | |
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試料 | - 複合体: human Trap1 in complex with SdhB in the presence of AMP-PNP
![](img/lk-wikipe.gif) - タンパク質・ペプチド: Heat shock protein 75 kDa, mitochondrial
Heat shock response - タンパク質・ペプチド: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
- リガンド: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
- リガンド: MAGNESIUM ION
- リガンド: POTASSIUM ION
カリウム |
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キーワード | Hsp90 (Hsp90) / CHAPERONE (シャペロン) / TRAP1 / SdhB / mitochondria (ミトコンドリア) |
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機能・相同性 | 機能・相同性情報
translational attenuation / negative regulation of cellular respiration / mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) / mitochondrial electron transport, succinate to ubiquinone / : / コハク酸デヒドロゲナーゼ / succinate dehydrogenase (quinone) activity / Citric acid cycle (TCA cycle) / Respiratory electron transport / tumor necrosis factor receptor binding ...translational attenuation / negative regulation of cellular respiration / mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) / mitochondrial electron transport, succinate to ubiquinone / : / コハク酸デヒドロゲナーゼ / succinate dehydrogenase (quinone) activity / Citric acid cycle (TCA cycle) / Respiratory electron transport / tumor necrosis factor receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / 3 iron, 4 sulfur cluster binding / ubiquinone binding / proton motive force-driven mitochondrial ATP synthesis / chaperone-mediated protein folding / negative regulation of reactive oxygen species biosynthetic process / 細胞呼吸 / クエン酸回路 / respiratory electron transport chain / cell periphery / ミトコンドリア / ATP-dependent protein folding chaperone / ミトコンドリア / 2 iron, 2 sulfur cluster binding / unfolded protein binding / フォールディング / 4 iron, 4 sulfur cluster binding / ミトコンドリア内膜 / electron transfer activity / ミトコンドリアマトリックス / protein kinase binding / ATP hydrolysis activity / ミトコンドリア / RNA binding / 核質 / ATP binding / 生体膜 / metal ion binding / 細胞膜類似検索 - 分子機能 4Fe-4S dicluster domain / Succinate dehydrogenase/fumarate reductase iron-sulphur protein / Succinate dehydogenase/fumarate reductase N-terminal / 2Fe-2S iron-sulfur cluster binding domain / Alpha-helical ferredoxin / 2Fe-2S ferredoxin, iron-sulphur binding site / 2Fe-2S ferredoxin-type iron-sulfur binding region signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family ...4Fe-4S dicluster domain / Succinate dehydrogenase/fumarate reductase iron-sulphur protein / Succinate dehydogenase/fumarate reductase N-terminal / 2Fe-2S iron-sulfur cluster binding domain / Alpha-helical ferredoxin / 2Fe-2S ferredoxin, iron-sulphur binding site / 2Fe-2S ferredoxin-type iron-sulfur binding region signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Beta-grasp domain superfamily / 2Fe-2S ferredoxin-type iron-sulfur binding domain profile. / 2Fe-2S ferredoxin-type iron-sulfur binding domain / 2Fe-2S ferredoxin-like superfamily / 4Fe-4S ferredoxin, iron-sulphur binding, conserved site / 4Fe-4S ferredoxin-type iron-sulfur binding region signature. / 4Fe-4S ferredoxin-type iron-sulfur binding domain profile. / 4Fe-4S ferredoxin-type, iron-sulphur binding domain / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold類似検索 - ドメイン・相同性 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial / Heat shock protein 75 kDa, mitochondrial類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.14 Å |
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データ登録者 | Liu YX / Agard DA |
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資金援助 | 米国, 6件 Organization | Grant number | 国 |
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Howard Hughes Medical Institute (HHMI) | | 米国 | American Heart Association | 18POST33990362 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM118099 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | U54CA209891 | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | U01MH115747 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | U19AI135990 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates 著者: Liu YX / Agard DA / Elnatan D / Sun M / Myasnikov AG |
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履歴 | 登録 | 2020年10月6日 | - |
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ヘッダ(付随情報) 公開 | 2021年10月13日 | - |
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マップ公開 | 2021年10月13日 | - |
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更新 | 2024年5月29日 | - |
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現状 | 2024年5月29日 | 処理サイト: RCSB / 状態: 公開 |
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