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Structure paper

TitleAllosteric disordering of eIF2B regulates the integrated stress response
Journal, issue, pagesNat. Chem. Biol., Year 2026
Publish dateSep 2, 2025 (structure data deposition date)
AuthorsDalwadi U / Subramanian A / Deal A / Conrad JE / Nadjsombati T / Venkatesh M / Boone M / Egea PF / He L / Jain N ...Dalwadi U / Subramanian A / Deal A / Conrad JE / Nadjsombati T / Venkatesh M / Boone M / Egea PF / He L / Jain N / Lee DJ / Liu Y / Reineke LC / Saito K / Talledge N / Toutkoushian H / Le Vasseur M / Zappa F / de Groot RJ / Acosta-Alvear D / Arthur CP / Nunnari J / Marqusee S / Lawrence RE / Costa-Mattioli M / Crawford JJ / van Kuppeveld FJM / Croll TI / Walter P / Frost A
External linksNat. Chem. Biol. / Search PubMed
MethodsEM (single particle)
Resolution2.1 - 3.3 Å
Structure data

72462

9y3p

EMDB-72462: Eukaryotic translation initiation factor 2-B in its apo form (active-state) (CASP target)
PDB-9y3p: Eukaryotic translation initiation factor 2-B in its apo form (active-state)
Method: EM (single particle) / Resolution: 2.9 Å

72463

9y3q

EMDB-72463: Eukaryotic translation initiation factor 2-B in its apo form (inactive-state) (CASP target)
PDB-9y3q: Eukaryotic translation initiation factor 2-B in its apo form (inactive-state)
Method: EM (single particle) / Resolution: 3.3 Å

72466

9y3t

EMDB-72466: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) (CASP target)
PDB-9y3t: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state)
Method: EM (single particle) / Resolution: 2.5 Å

72467

9y3u

EMDB-72467: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (inactive state) (CASP target)
PDB-9y3u: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (inactive state)
Method: EM (single particle) / Resolution: 2.4 Å

72468

9y3v

EMDB-72468, PDB-9y3v:
Eukaryotic translation initiation factor 2-B (eIF2B) bound to the viral effector AcP10
Method: EM (single particle) / Resolution: 2.9 Å

72477

9y4b

EMDB-72477: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) bound to the viral effector AcP10 (CASP target)
PDB-9y4b: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) bound to the viral effector AcP10
Method: EM (single particle) / Resolution: 2.1 Å

72499

9y4w

EMDB-72499: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) asymmetrically bound to the viral effector AcP10 (CASP target)
PDB-9y4w: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) asymmetrically bound to the viral effector AcP10
Method: EM (single particle) / Resolution: 2.4 Å

72520
EMDB Unreleased entry

9y5r

EMDB-72520, PDB-9y5r:
Eukaryotic translation initiation factor 2-B (eIF2B) bound to phosphorylated eIF2alpha (NTD)
Method: EM (single particle) / Resolution: 3.01 Å

72521
EMDB Unreleased entry

9y5s

EMDB-72521, PDB-9y5s:
eIF2B lacking the latch helix bound to ISRACT-01 (Inactive state)
Method: EM (single particle) / Resolution: 3.1 Å

72522
EMDB Unreleased entry

9y5t

EMDB-72522, PDB-9y5t:
eIF2B lacking the latch helix bound to ISRACT-02 (Active state)
Method: EM (single particle) / Resolution: 2.78 Å

72523
EMDB Unreleased entry

9y5u

EMDB-72523, PDB-9y5u:
eIF2B lacking the latch helix bound to ISRACT-02 (Inactive state)
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-IMD:
IMIDAZOLE

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

PDB-1css:
ALPHA-FLUORO ACID AND ALPHA-FLUORO AMIDE ANALOGS OF ACETYL-COA AS INHIBITORS OF OF CITRATE SYNTHASE: EFFECT OF PKA MATCHING ON BINDING AFFINITY AND HYDROGEN BOND LENGTH

PDB-1csr:
Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length

Source
  • homo sapiens (human)
  • beluga whale coronavirus sw1
KeywordsTRANSLATION / Guanine nucleotide exchange factor / GEF / initiation

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