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Structure paper

TitleMolecular mechanism of allosteric modulation of opioid receptors.
Journal, issue, pagesSignal Transduct Target Ther, Vol. 11, Year 2026
Publish dateOct 29, 2025
AuthorsWang, H. / Miao, Z. / Zhao, C. / Fu, H. / Tian, X. / Liu, X. / Wang, L. / Liu, Y. / Yong, X. / Su, L. ...Wang, H. / Miao, Z. / Zhao, C. / Fu, H. / Tian, X. / Liu, X. / Wang, L. / Liu, Y. / Yong, X. / Su, L. / Yan, W. / Cheng, L. / Chai, R. / Shao, Z. / Ke, B.
External linksSignal Transduct Target Ther / PubMed:42362532
MethodsEM (single particle)
Resolution2.52 - 3.22 Å
Structure data

66723
EMDB entry, No image

EMDB-66723, PDB-9xc6:
Cryo-EM structure of BMS-986187-bound MOR-Gi1 complex
Method: EM (single particle) / Resolution: 3.04 Å


EMDB entry, No image

EMDB-66725: BMS-986187-bound MOR-Gi1 G Protein EM map
Method: EM (single particle) / Resolution: 3.04 Å


EMDB entry, No image

EMDB-66726: The overall map of BMS-986187-bound MOR-Gi1 complex
Method: EM (single particle) / Resolution: 3.04 Å


EMDB entry, No image

EMDB-66730: The receptor local map of BMS-986187-bound MOR-Gi1 complex
Method: EM (single particle) / Resolution: 3.04 Å

66771
EMDB entry, No image

EMDB-66771, PDB-9xdq:
Cryo-EM structure of BMS986187 bound DOR-Gi complex
Method: EM (single particle) / Resolution: 2.79 Å

66773
EMDB entry, No image

EMDB-66773, PDB-9xdr:
Cryo-EM structure of asimadoline-BMS-986187-bound KOR-Gi1 complex
Method: EM (single particle) / Resolution: 2.58 Å

66801
EMDB entry, No image

EMDB-66801, PDB-9xf4:
Cryo-EM structure of Leu-enkephalin-BMS-986187-bound DOR-Gi2 complex
Method: EM (single particle) / Resolution: 3.05 Å


EMDB entry, No image

EMDB-66825: The receptor local map of BMS-986187-bound DOR-Gi2 complex
Method: EM (single particle) / Resolution: 2.95 Å


EMDB entry, No image

EMDB-66826: The G PROTEIN map of BMS-986187-bound DOR-Gi1 complex
Method: EM (single particle) / Resolution: 2.66 Å


EMDB entry, No image

EMDB-66827: The overall map of BMS-986187-bound DOR-Gi2 complex
Method: EM (single particle) / Resolution: 2.79 Å


EMDB entry, No image

EMDB-66828: The receptor local map of asimadoline-BMS-986187-bound KOR-Gi1 complex
Method: EM (single particle) / Resolution: 2.73 Å


EMDB entry, No image

EMDB-66829: The G PROTEIN map of asimadoline-BMS-986187-bound KOR-Gi1 complex
Method: EM (single particle) / Resolution: 2.52 Å


EMDB entry, No image

EMDB-66830: The overall map of asimadoline-BMS-986187-bound KOR-Gi1 complex
Method: EM (single particle) / Resolution: 2.58 Å


EMDB entry, No image

EMDB-66831: The receptor local map of Leu-enkephalin-BMS-986187-bound DOR-Gi complex
Method: EM (single particle) / Resolution: 3.22 Å


EMDB entry, No image

EMDB-66832: The Gi protein local map of Leu-enkephalin-BMS-986187-bound DOR-Gi complex
Method: EM (single particle) / Resolution: 2.87 Å


EMDB entry, No image

EMDB-66833: The overall map of Leu-enkephalin-BMS-986187-bound DOR-Gi complex
Method: EM (single particle) / Resolution: 3.05 Å

Chemicals

PDB-1d6b:
SOLUTION STRUCTURE OF DEFENSIN-LIKE PEPTIDE-2 (DLP-2) FROM PLATYPUS VENOM

PDB-1esg:
RESTRICTION ENDONUCLEASE BAMHI BOUND TO A NON-SPECIFIC DNA.

PDB-1e0f:
Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

Source
  • homo sapiens (human)
  • oplophorus gracilirostris (arthropod)
  • synthetic construct (others)
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / Complex / Agonist / PAM

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