EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail.
ジャーナル・号・ページ	Sci Adv, Vol. 11, Issue 40, Page eadx1178, Year 2025
掲載日	2025年10月3日
著者	Daniel X Zhang / Michail N Isupov / Rebecca M Davies / Sabine Schwarzer / Mathew McLaren / William S Stuart / Vicki A M Gold / Hanna M Oksanen / Tessa E F Quax / Bertram Daum /
PubMed 要旨	While archaeal viruses show a stunning diversity of morphologies, many bear a notable resemblance to tailed bacterial phages. This raises fundamental questions: Do all tailed viruses share a common ...While archaeal viruses show a stunning diversity of morphologies, many bear a notable resemblance to tailed bacterial phages. This raises fundamental questions: Do all tailed viruses share a common origin and do they infect their hosts in similar ways? Answering these questions requires high-resolution structural insights, yet no complete atomic models of archaeal viruses have been available. Here, we present the near-atomic resolution structure of Haloferax tailed virus 1 (HFTV1), an archaeal virus thriving in extreme salinity. Using cryo-electron microscopy, we resolve the architecture and assembly of all structural proteins and capture conformational transitions associated with DNA ejection. Our data reveal genome spooling within the capsid and identify putative receptor-binding and catalytic sites for host recognition and infection. These findings uncover key mechanisms of archaeal virus assembly, principles of virus-host interactions, and evolutionary links connecting archaeal, bacterial, and eukaryotic viruses.
リンク	Sci Adv / PubMed:41042861 / PubMed Central
手法	EM (単粒子)
解像度	2.342 - 3.6 Å
構造データ	18550 8qpg EMDB-18550, PDB-8qpg: Turret of Haloferax tailed virus 1 手法: EM (単粒子) / 解像度: 2.36 Å 18559 8qpq EMDB-18559, PDB-8qpq: C1 turret to capsid interface of full Haloferax tailed virus 1 adjacent to the portal-capsid interface. 手法: EM (単粒子) / 解像度: 2.7 Å 18599 8qqn EMDB-18599, PDB-8qqn: Portal protein of full Haloferax tailed virus 1. 手法: EM (単粒子) / 解像度: 2.342 Å 18633 8qsi EMDB-18633, PDB-8qsi: Portal protein of empty Haloferax tailed virus 1. 手法: EM (単粒子) / 解像度: 2.75 Å 18642 8qsy EMDB-18642, PDB-8qsy: Portal capsid interface of full Haloferax tailed virus 1. 手法: EM (単粒子) / 解像度: 2.68 Å 50521 9fkb EMDB-50521, PDB-9fkb: Tail of emppty Haloferax tailed virus 1 手法: EM (単粒子) / 解像度: 2.96 Å 51530 9gs0 EMDB-51530, PDB-9gs0: Capsid of full Haloferax tailed virus 1 without turret head protein gp31. 手法: EM (単粒子) / 解像度: 2.37 Å 51866 9h4p EMDB-51866, PDB-9h4p: Tail of full Haloferax tailed virus 1 手法: EM (単粒子) / 解像度: 2.44 Å 51883 9h5b EMDB-51883, PDB-9h5b: Tail fibre of Haloferax tailed virus 1 手法: EM (単粒子) / 解像度: 3.6 Å 51915 9h7v EMDB-51915, PDB-9h7v: The baseplate assembly of Haloferax tailed virus 1. 手法: EM (単粒子) / 解像度: 2.6 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-K: Unknown entry / カリウムカチオン
由来	haloferax tailed virus 1 (ウイルス)
キーワード	VIRUS / Archeal virus / turret / turret capsid interface / Mg ions / Archaeal virus / portal / portal capsid interface / tail / capsid / baseplate / tape measure protein / tail fiber