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Structure paper

TitleTargeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
Journal, issue, pagesTo Be Published
Publish dateOct 18, 2024 (structure data deposition date)
AuthorsMiotto MC
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.12 - 4.49 Å
Structure data

EMDB-47357: Structure of RyR1 in the primed state in the presence of caffeine - focused map (reprocessed from EMPIAR-10997)
Method: EM (single particle) / Resolution: 2.12 Å

47385

9e18

EMDB-47385, PDB-9e18:
Structure of RyR1 in the primed state in the presence of pentoxifylline
Method: EM (single particle) / Resolution: 2.68 Å

47386

9e19

EMDB-47386, PDB-9e19:
Structure of RyR1 in the open state in the presence of pentoxifylline
Method: EM (single particle) / Resolution: 4.04 Å

47387

9e1a

EMDB-47387, PDB-9e1a:
Structure of RyR1 in the primed state in the presence of dyphylline
Method: EM (single particle) / Resolution: 3.35 Å

47388

9e1b

EMDB-47388, PDB-9e1b:
Structure of RyR1 in the open state in the presence of dyphylline
Method: EM (single particle) / Resolution: 4.49 Å

47389

9e1c

EMDB-47389, PDB-9e1c:
Structure of RyR1 in the primed state in the presence of IBMX
Method: EM (single particle) / Resolution: 2.63 Å

47390

9e1d

EMDB-47390, PDB-9e1d:
Structure of RyR1 in the primed state in the presence of enprofylline
Method: EM (single particle) / Resolution: 2.76 Å

47391

9e1e

EMDB-47391, PDB-9e1e:
Structure of RyR1 in the primed state in the presence of uracil
Method: EM (single particle) / Resolution: 2.92 Å

47392

9e1f

EMDB-47392, PDB-9e1f:
Structure of RyR1 in the primed state in the presence of allopurinol
Method: EM (single particle) / Resolution: 3.03 Å

47393

9e1g

EMDB-47393, PDB-9e1g:
Structure of RyR1 in the primed state in the presence of oxypurinol
Method: EM (single particle) / Resolution: 3.17 Å

47394

9e1h

EMDB-47394, PDB-9e1h:
Structure of RyR1 in the primed state in the presence of oxopyricid
Method: EM (single particle) / Resolution: 3.26 Å

47395

9e1i

EMDB-47395, PDB-9e1i:
Structure of RyR1 in the open state in the presence of oxopyricid
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-47396: Structure of RyR1 in the primed state in the presence of pentoxifylline, focused refinement
Method: EM (single particle) / Resolution: 2.35 Å

EMDB-47397: Structure of RyR1 in the open state in the presence of pentoxifylline, focused refinement
Method: EM (single particle) / Resolution: 3.49 Å

EMDB-47398: Structure of RyR1 in the primed state in the presence of dyphylline, focused refinement
Method: EM (single particle) / Resolution: 3.14 Å

EMDB-47399: Structure of RyR1 in the open state in the presence of dyphylline, focused refinement
Method: EM (single particle) / Resolution: 4.16 Å

EMDB-47400: Structure of RyR1 in the primed state in the presence of IBMX, focused refinement
Method: EM (single particle) / Resolution: 2.34 Å

EMDB-47401: Structure of RyR1 in the primed state in the presence of enprofylline, focused refinement
Method: EM (single particle) / Resolution: 2.42 Å

EMDB-47402: Structure of RyR1 in the primed state in the presence of uracil, focused refinement
Method: EM (single particle) / Resolution: 2.47 Å

EMDB-47403: Structure of RyR1 in the primed state in the presence of allopurinol, focused refinement
Method: EM (single particle) / Resolution: 2.56 Å

EMDB-47404: Structure of RyR1 in the primed state in the presence of oxypurinol, focused refinement
Method: EM (single particle) / Resolution: 2.69 Å

EMDB-47405: Structure of RyR1 in the primed state in the presence of oxopyricid, focused refinement
Method: EM (single particle) / Resolution: 2.64 Å

EMDB-47406: Structure of RyR1 in the open state in the presence of oxopyricid, focused refinement
Method: EM (single particle) / Resolution: 2.65 Å

PDB-9e17:
Structure of RyR1 in the primed state in the presence of caffeine (reprocessed/reanalyzed from EMPIAR-10997, 7TZC, EMD-26205)
Method: ELECTRON MICROSCOPY / Resolution: 2.45 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-ZN:
Unknown entry

ChemComp-CFF:
CAFFEINE / medication*YM

ChemComp-KVR:
4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid

ChemComp-L9R:
(2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / SOPC, phospholipid*YM

ChemComp-HOH:
WATER

ChemComp-PNX:
3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE

PDB-1bd2:
COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201

ChemComp-IBM:
3-ISOBUTYL-1-METHYLXANTHINE / inhibitor, antagonist*YM

PDB-1bd3:
STRUCTURE OF THE APO URACIL PHOSPHORIBOSYLTRANSFERASE, 2 MUTANT C128V

ChemComp-URA:
URACIL

PDB-1bd4:
UPRT-URACIL COMPLEX

ChemComp-141:
Oxypurinol / inhibitor*YM

PDB-1bd5:
Unknown entry

Source
  • oryctolagus cuniculus (rabbit)
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / calcium channel / sarcoplasmic reticulum

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