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Structure paper

TitleStructural insight on tailored modulation of TLR4-mediated pro-inflammatory response by disaccharide lipid A mimetics
Journal, issue, pagesTo Be Published
Publish dateOct 16, 2023 (structure data deposition date)
AuthorsFu Y / Kim H
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.6 - 3.1 Å
Structure data

37794

8wry

EMDB-37794, PDB-8wry:
Cryo-EM Structure of Mouse TLR4/MD-2/DLAM3 Complex
Method: EM (single particle) / Resolution: 2.6 Å

37803

8wsa

EMDB-37803, PDB-8wsa:
Cryo-EM Structure of Mouse TLR4/MD-2/DLAM5 Complex
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-2IL:
(3R)-3-(dodecanoyloxy)tetradecanoic acid


ChemComp, No image

ChemComp-0IL:
Unknown entry


ChemComp, No image

ChemComp-XIQ:
Unknown entry

ChemComp-GP4:
2-amino-2-deoxy-4-O-phosphono-alpha-D-glucopyranose


ChemComp, No image

ChemComp-X6N:
Unknown entry

PDB-1l01:
STRUCTURAL STUDIES OF MUTANTS OF THE LYSOZYME OF BACTERIOPHAGE T4. THE TEMPERATURE-SENSITIVE MUTANT PROTEIN THR157 (RIGHT ARROW) ILE

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Innate immune system / Toll-like receptors / TLR4 agonist / Vaccine adjuvants / Disaccharide-based Lipid A Mimetics

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