Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Journal, issue, pages	Nat Catal, Vol. 5, Page 332-341, Year 2022
Publish date	Apr 28, 2020 (structure data deposition date)
Authors	Rindfleisch, S. / Krull, M. / Uranga, J. / Schmidt, T. / Rabe von Pappenheim, F. / Kirck, L.L. / Balouri, A. / Schneider, T. / Chari, A. / Kluger, R. ...Rindfleisch, S. / Krull, M. / Uranga, J. / Schmidt, T. / Rabe von Pappenheim, F. / Kirck, L.L. / Balouri, A. / Schneider, T. / Chari, A. / Kluger, R. / Bourenkov, G. / Diederichsen, U. / Mata, R.A. / Tittmann, K.
External links	Nat Catal / Search PubMed
Methods	X-ray diffraction
Resolution	0.9 - 1.31 Å
Structure data	PDB-6yvk: Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 0.71 MGy exposure Method: X-RAY DIFFRACTION / Resolution: 1.25 Å PDB-6yvl: Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 1.42 MGy exposure Method: X-RAY DIFFRACTION / Resolution: 1.25 Å PDB-6yvm: Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.13 MGy exposure Method: X-RAY DIFFRACTION / Resolution: 1.25 Å PDB-6yvn: Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.84 MGy exposure Method: X-RAY DIFFRACTION / Resolution: 1.25 Å PDB-6yvo: Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 3.55 MGy exposure Method: X-RAY DIFFRACTION / Resolution: 1.25 Å PDB-6ywt: Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1.05 Å PDB-6ywu: Human OMPD-domain of UMPS (K314AcK) in complex with UMP at 1.1 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1.1 Å PDB-6zwy: OMPD-domain of human UMPS in complex with UMP at 1.0 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1 Å PDB-6zwz: Resting state structure of the OMPD-domain of human UMPS variant (K314AcK) at 1.2 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1.2 Å PDB-6zx0: OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1.25 Å PDB-6zx1: OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1 Å PDB-6zx2: OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1.2 Å PDB-6zx3: OMPD-domain of human UMPS in complex with 6-thiocarboxamido-UMP at 1.15 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 1.15 Å PDB-7am9: OMPD-domain of human UMPS in complex with the substrate OMP at 0.99 Angstroms resolution Method: X-RAY DIFFRACTION / Resolution: 0.99 Å PDB-7asq: Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the reaction product UMP at 0.95 Angstrom resolution Method: X-RAY DIFFRACTION / Resolution: 0.95 Å PDB-7oqf: Human OMPD-domain of UMPS in complex with OMP at 1.05 Angstrom resolution, 5 minutes soaking Method: X-RAY DIFFRACTION / Resolution: 1.05 Å PDB-7oqi: Human OMPD-domain of UMPS in complex with substrate OMP at 1.15 Angstrom resolution, 10 minutes soaking Method: X-RAY DIFFRACTION / Resolution: 1.15 Å PDB-7oqk: Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 15 minutes soaking Method: X-RAY DIFFRACTION / Resolution: 1.1 Å PDB-7oqm: Human OMPD-domain of UMPS in complex with substrate OMP at 1.05 Angstroms resolution, 20 minutes soaking Method: X-RAY DIFFRACTION / Resolution: 1.05 Å PDB-7oqn: Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 30 minutes soaking Method: X-RAY DIFFRACTION / Resolution: 1.1 Å PDB-7otu: Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2 Method: X-RAY DIFFRACTION / Resolution: 0.95 Å PDB-7ouz: Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.9 Angstroms resolution, crystal 1 Method: X-RAY DIFFRACTION / Resolution: 0.9 Å PDB-7ov0: Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in resting state at 0.95 Angstrom resolution Method: X-RAY DIFFRACTION / Resolution: 0.95 Å PDB-7q1h: Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution Method: X-RAY DIFFRACTION / Resolution: 1.31 Å
Chemicals	ChemComp-OMP: OROTIDINE-5'-MONOPHOSPHATE ChemComp-U: URIDINE-5'-MONOPHOSPHATE ChemComp-GOL: GLYCEROL ChemComp-SO4: SULFATE ION ChemComp-HOH: WATER ChemComp-BMP: 6-HYDROXYURIDINE-5'-PHOSPHATE ChemComp-PRO: PROLINE ChemComp-U5P: URIDINE-5'-MONOPHOSPHATE ChemComp-UP6: 6-AZA URIDINE 5'-MONOPHOSPHATE ChemComp-QRT: [(2~{R},3~{S},4~{R},5~{R})-5-[6-aminocarbonyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate ChemComp-QRZ: [(2~{R},3~{S},4~{R},5~{R})-5-[6-carbamothioyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate ChemComp-NA: Unknown entry
Source	homo sapiens (human)
Keywords	LYASE / OMPD / OMP / UMPS / Orotidine 5'-monophosphate decarboxylase / BMP / UMP / 6-carboxamido-UMP / NUCLEIC ACID METABOLISM