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Structure paper

TitleStructural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.
Journal, issue, pagesCommun Biol, Vol. 5, Page 263-263, Year 2022
Publish dateJan 26, 2016 (structure data deposition date)
AuthorsStogios, P.J. / Bordeleau, E. / Xu, Z. / Skarina, T. / Evdokimova, E. / Chou, S. / Diorio-Toth, L. / D'Souza, A.W. / Patel, S. / Dantas, G. ...Stogios, P.J. / Bordeleau, E. / Xu, Z. / Skarina, T. / Evdokimova, E. / Chou, S. / Diorio-Toth, L. / D'Souza, A.W. / Patel, S. / Dantas, G. / Wright, G.D. / Savchenko, A.
External linksCommun Biol / PubMed:35338238
MethodsX-ray diffraction
Resolution1.92 - 3.3 Å
Structure data

PDB-5ht0:
Crystal structure of an Antibiotic_NAT family aminoglycoside acetyltransferase HMB0038 from an uncultured soil metagenomic sample in complex with coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.752 Å

PDB-6mmz:
Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, H29A mutant apoenzyme
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-6mn0:
Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, H168A mutant in complex with acetyl-CoA
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6mn3:
Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, apoenzyme
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6mn4:
Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, H154A mutant, in complex with apramycin
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6mn5:
Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, H154A mutant, in complex with gentamicin C1A
Method: X-RAY DIFFRACTION / Resolution: 2.58 Å

PDB-7kes:
Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in complex with apramycin and CoA
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

PDB-7lao:
Crystal structure of aminoglycoside acetyltransferase AAC(3)-IIb
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-7lap:
Crystal structure of aminoglycoside acetyltransferase AAC(3)-Xa
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

Chemicals

ChemComp-COA:
COENZYME A

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-ACO:
ACETYL COENZYME *A

ChemComp-GOL:
GLYCEROL

ChemComp-PE3:
3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL

ChemComp-ZN:
Unknown entry

ChemComp-AM2:
APRAMYCIN / antibiotic*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-LLL:
(2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR

ChemComp-MG:
Unknown entry

ChemComp-TAR:
D(-)-TARTARIC ACID

ChemComp-FMT:
FORMIC ACID

Source
  • uncultured bacterium (environmental samples)
  • escherichia coli (E. coli)
  • serratia marcescens (bacteria)
  • streptomyces griseus (bacteria)
KeywordsTRANSFERASE / Antibiotic_NAT family / ACETYLTRANSFERASE / AMINOGLYCOSIDE / ANTIBIOTIC RESISTANCE / METAGENOME / SOIL / COENZYME A / CSGID / Center for Structural Genomics of Infectious Diseases / National Institute of Allergy and Infectious Diseases / NIAID / gentamicin / AAC(3)-IVA / TRANSFERASE/ANTIBIOTIC / APRAMYCIN / TRANSFERASE-ANTIBIOTIC complex / AAC(3)-IIb / RESISTANCE / AAC(3)-Xa

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