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| Title | Structure of faustovirus, a large dsDNA virus. |
|---|---|
| Journal, issue, pages | Proc Natl Acad Sci U S A, Vol. 113, Issue 22, Page 6206-6211, Year 2016 |
| Publish date | May 31, 2016 |
 Authors | Thomas Klose / Dorine G Reteno / Samia Benamar / Adam Hollerbach / Philippe Colson / Bernard La Scola / Michael G Rossmann /   |
| PubMed Abstract | Many viruses protect their genome with a combination of a protein shell with or without a membrane layer. Here we describe the structure of faustovirus, the first DNA virus (to our knowledge) that ...Many viruses protect their genome with a combination of a protein shell with or without a membrane layer. Here we describe the structure of faustovirus, the first DNA virus (to our knowledge) that has been found to use two protein shells to encapsidate and protect its genome. The crystal structure of the major capsid protein, in combination with cryo-electron microscopy structures of two different maturation stages of the virus, shows that the outer virus shell is composed of a double jelly-roll protein that can be found in many double-stranded DNA viruses. The structure of the repeating hexameric unit of the inner shell is different from all other known capsid proteins. In addition to the unique architecture, the region of the genome that encodes the major capsid protein stretches over 17,000 bp and contains a large number of introns and exons. This complexity might help the virus to rapidly adapt to new environments or hosts. |
 External links | Proc Natl Acad Sci U S A / PubMed:27185929 / PubMed Central |
| Methods | EM (single particle) / X-ray diffraction |
| Resolution | 2.37 - 26.4 Å |
| Structure data | EMDB-8144: Faustovirus  EMDB-8145:  PDB-5j7o:  PDB-5j7u: |
| Chemicals |  ChemComp-HOH: |
| Source |
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 Keywords | VIRAL PROTEIN / virus / capsid / double jelly-roll |
faustovirus