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Structure paper

TitleAllostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states.
Journal, issue, pagesBiochemistry, Vol. 52, Page 6396-6411, Year 2013
Publish dateOct 18, 2012 (structure data deposition date)
AuthorsNiks, D. / Hilario, E. / Dierkers, A. / Ngo, H. / Borchardt, D. / Neubauer, T.J. / Fan, L. / Mueller, L.J. / Dunn, M.F.
External linksBiochemistry / PubMed:23952479
MethodsX-ray diffraction
Resolution1.3 - 1.77 Å
Structure data

PDB-4hn4:
Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor in the alpha site
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

PDB-4hpj:
Crystal structure of Tryptophan Synthase at 1.45 A resolution in complex with 2-aminophenol quinonoid in the beta site and the F9 inhibitor in the alpha site
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-4hpx:
Crystal structure of Tryptophan Synthase at 1.65 A resolution in complex with alpha aminoacrylate E(A-A) and benzimidazole in the beta site and the F9 inhibitor in the alpha site
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-4ht3:
The crystal structure of Salmonella typhimurium Tryptophan Synthase at 1.30A complexed with N-(4'-TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1-ETHYLPHOSPHATE (F9) inhibitor in the alpha site, internal aldimine
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-4kkx:
Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

Chemicals

ChemComp-F9F:
2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE

ChemComp-0JO:
2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-BCN:
BICINE / pH buffer*YM

ChemComp-CS:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-1D0:
(2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]-3-[(2-hydroxyphenyl)amino]propanoic acid

ChemComp-BZI:
BENZIMIDAZOLE

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-PG5:
1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-F6F:
2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE

ChemComp-NA:
Unknown entry

ChemComp-AQ3:
N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-3-[(2-hydroxyphenyl)amino]-D-alanine

Source
  • salmonella enterica subsp. enterica serovar typhimurium (bacteria)
KeywordsLYASE/LYASE INHIBITOR / Lyase / carbon-oxygen lyase / tryptophan biosynthesis / Salmonella / F9F / Allosteric enzyme / Amino-acid biosynthesis / Aromatic amino acid biosynthesis / Pyridoxal phosphate / alpha amino acrylate / LYASE-LYASE INHIBITOR complex / benzimidazole / Cesium ion / F6F / 2-aminophenol quinonoid / biosynthesis

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