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Structure paper

TitleAntibody Multispecificity Mediated by Conformational Diversity
Journal, issue, pagesScience, Vol. 299, Page 1362-, Year 2003
Publish dateJan 21, 2003 (structure data deposition date)
AuthorsJames, L.C. / Roversi, P. / Tawfik, D.
External linksScience / PubMed:12610298
MethodsX-ray diffraction
Resolution1.5 - 2.78 Å
Structure data

PDB-1oaq:
Free conformation Ab1 of the IgE SPE-7
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-1oar:
Fv IgE SPE-7 in complex with Alizarin Red
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

PDB-1oau:
Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1oax:
Fv Structure of the IgE SPE-7 in complex with acenaphthenequinone
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

PDB-1oay:
Antibody multispecificity mediated by conformational diversity
Method: X-RAY DIFFRACTION / Resolution: 2.66 Å

PDB-1oaz:
IgE Fv SPE7 complexed with a recombinant thioredoxin
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

PDB-1ocw:
Free conformation Ab2 of the IgE SPE-7
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CAC:
CACODYLATE ION

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-AZN:
ALIZARIN RED

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-SER:
SERINE

ChemComp-DNF:
2,4-DINITROPHENOL

ChemComp-IMD:
IMIDAZOLE

ChemComp-ANQ:
ACENAPHTHENEQUINONE

ChemComp-FUR:
Furazolidone / antibiotic, inhibitor*YM

Source
  • mus musculus (house mouse)
  • escherichia coli (E. coli)
KeywordsIMMUNE SYSTEM / ALLERGY / IGE / CONFORMATIONAL DIVERSITY / MULTISPECIFICITY / ANTIBODY-COMPLEX / ANTIBODY / MULTISPECFICITY / REDOX-ACTIVE CENTER / ELECTRON TRANSPORT

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