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Keywords
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Author
Journal
IF

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Structure paper

TitleAllosteric Disordering of eIF2B Regulates the Integrated Stress Response
Journal, issue, pagesTo Be Published
Publish dateSep 2, 2025 (structure data deposition date)
AuthorsDalwadi U / Subramanian A / Croll T / Lee DJ / Arthur C / Walter P / Frost A
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.1 - 3.3 Å
Structure data

72463

9y3q

EMDB-72463: Eukaryotic translation initiation factor 2-B in its apo form (inactive-state) (CASP target)
PDB-9y3q: Eukaryotic translation initiation factor 2-B in its apo form (inactive-state)
Method: EM (single particle) / Resolution: 3.3 Å

72466

9y3t

EMDB-72466: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) (CASP target)
PDB-9y3t: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state)
Method: EM (single particle) / Resolution: 2.5 Å

72467

9y3u

EMDB-72467: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (inactive state) (CASP target)
PDB-9y3u: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (inactive state)
Method: EM (single particle) / Resolution: 2.4 Å

72468

9y3v

EMDB-72468, PDB-9y3v:
Eukaryotic translation initiation factor 2-B (eIF2B) bound to the viral effector AcP10
Method: EM (single particle) / Resolution: 2.9 Å

72477

9y4b

EMDB-72477: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) bound to the viral effector AcP10 (CASP target)
PDB-9y4b: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) bound to the viral effector AcP10
Method: EM (single particle) / Resolution: 2.1 Å

72499

9y4w

EMDB-72499: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) asymmetrically bound to the viral effector AcP10 (CASP target)
PDB-9y4w: Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) asymmetrically bound to the viral effector AcP10
Method: EM (single particle) / Resolution: 2.4 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • beluga whale coronavirus sw1
KeywordsTRANSLATION / Guanine nucleotide exchange factor / GEF / initiation

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