| Title | Structure and activation mechanism of human sweet taste receptor. |
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| Journal, issue, pages | Cell Res, Vol. 35, Issue 10, Page 775-778, Year 2025 |
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| Publish date | Aug 4, 2025 |
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Authors | Haolan Wang / Xiao Chen / Yaxin Dai / Shabareesh Pidathala / Yiming Niu / Chen Zhao / Siyu Li / Liang Wang / Chia-Hsueh Lee /  |
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External links | Cell Res / PubMed:40754567 / PubMed Central |
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| Methods | EM (single particle) |
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| Resolution | 2.84 - 4.49 Å |
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| Structure data | EMDB-70726: Structure of the sweet receptor in the apo state Method: EM (single particle) / Resolution: 3.07 Å EMDB-70727, PDB-9opw: Structure of the sweet receptor in the apo state, extracellular domain Method: EM (single particle) / Resolution: 2.86 Å EMDB-70728: Structure of the sweet receptor in the apo state, VFT domain Method: EM (single particle) / Resolution: 2.84 Å EMDB-70729, PDB-9opx: Structure of the sweet receptor in the apo state, transmembrane domain Method: EM (single particle) / Resolution: 3.63 Å EMDB-70730, PDB-9opy: Structure of the sweet receptor in the apo state Method: EM (single particle) / Resolution: 3.51 Å EMDB-70731, PDB-9opz: Structure of the sweet receptor bound to sucralose in the compact state, extracellular domain Method: EM (single particle) / Resolution: 3.16 Å EMDB-70732, PDB-9oq0: Structure of the sweet receptor bound to sucralose in the compact state, transmembrane domain Method: EM (single particle) / Resolution: 3.67 Å EMDB-70733, PDB-9oq1: Structure of the sweet receptor bound to sucralose in the loose state, extracellular domain Method: EM (single particle) / Resolution: 2.98 Å EMDB-70734: Structure of the sweet receptor bound to sucralose in the loose state, transmembrane domain Method: EM (single particle) / Resolution: 4.28 Å EMDB-70735, PDB-9oq2: Structure of the sweet receptor bound to advantame in the compact state, extracellular domain Method: EM (single particle) / Resolution: 3.27 Å EMDB-70736: Structure of the sweet receptor bound to advantame in the compact state, transmembrane domain Method: EM (single particle) / Resolution: 4.2 Å EMDB-70737, PDB-9oq3: Structure of the sweet receptor bound to advantame in the loose state, extracellular domain Method: EM (single particle) / Resolution: 3.11 Å EMDB-70738: Structure of the sweet receptor bound to advantame in the loose state, transmembrane domain Method: EM (single particle) / Resolution: 4.49 Å EMDB-70739, PDB-9oq4: Structure of the human sweet receptor bound to advantame in the compact state, extracellular domain Method: EM (single particle) / Resolution: 3.59 Å EMDB-70740, PDB-9oq5: Structure of the human sweet receptor bound to advantame in the intermediate state, extracellular domain Method: EM (single particle) / Resolution: 3.93 Å EMDB-70741, PDB-9oq6: Structure of the human sweet receptor bound to advantame in the loose state, extracellular domain Method: EM (single particle) / Resolution: 3.57 Å |
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| Chemicals | |
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| Source | homo sapiens (human) mus musculus (house mouse)
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Keywords | SIGNALING PROTEIN / Membrane protein / GPCR / apo state |
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