| タイトル | Structure and activation mechanism of human sweet taste receptor. |
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| ジャーナル・号・ページ | Cell Res, Vol. 35, Issue 10, Page 775-778, Year 2025 |
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| 掲載日 | 2025年8月4日 |
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著者 | Haolan Wang / Xiao Chen / Yaxin Dai / Shabareesh Pidathala / Yiming Niu / Chen Zhao / Siyu Li / Liang Wang / Chia-Hsueh Lee /  |
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リンク | Cell Res / PubMed:40754567 / PubMed Central |
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| 手法 | EM (単粒子) |
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| 解像度 | 2.84 - 4.49 Å |
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| 構造データ | EMDB-70726: Structure of the sweet receptor in the apo state 手法: EM (単粒子) / 解像度: 3.07 Å EMDB-70727, PDB-9opw: Structure of the sweet receptor in the apo state, extracellular domain 手法: EM (単粒子) / 解像度: 2.86 Å EMDB-70728: Structure of the sweet receptor in the apo state, VFT domain 手法: EM (単粒子) / 解像度: 2.84 Å EMDB-70729, PDB-9opx: Structure of the sweet receptor in the apo state, transmembrane domain 手法: EM (単粒子) / 解像度: 3.63 Å EMDB-70730, PDB-9opy: Structure of the sweet receptor in the apo state 手法: EM (単粒子) / 解像度: 3.51 Å EMDB-70731, PDB-9opz: Structure of the sweet receptor bound to sucralose in the compact state, extracellular domain 手法: EM (単粒子) / 解像度: 3.16 Å EMDB-70732, PDB-9oq0: Structure of the sweet receptor bound to sucralose in the compact state, transmembrane domain 手法: EM (単粒子) / 解像度: 3.67 Å EMDB-70733, PDB-9oq1: Structure of the sweet receptor bound to sucralose in the loose state, extracellular domain 手法: EM (単粒子) / 解像度: 2.98 Å EMDB-70734: Structure of the sweet receptor bound to sucralose in the loose state, transmembrane domain 手法: EM (単粒子) / 解像度: 4.28 Å EMDB-70735, PDB-9oq2: Structure of the sweet receptor bound to advantame in the compact state, extracellular domain 手法: EM (単粒子) / 解像度: 3.27 Å EMDB-70736: Structure of the sweet receptor bound to advantame in the compact state, transmembrane domain 手法: EM (単粒子) / 解像度: 4.2 Å EMDB-70737, PDB-9oq3: Structure of the sweet receptor bound to advantame in the loose state, extracellular domain 手法: EM (単粒子) / 解像度: 3.11 Å EMDB-70738: Structure of the sweet receptor bound to advantame in the loose state, transmembrane domain 手法: EM (単粒子) / 解像度: 4.49 Å EMDB-70739, PDB-9oq4: Structure of the human sweet receptor bound to advantame in the compact state, extracellular domain 手法: EM (単粒子) / 解像度: 3.59 Å EMDB-70740, PDB-9oq5: Structure of the human sweet receptor bound to advantame in the intermediate state, extracellular domain 手法: EM (単粒子) / 解像度: 3.93 Å EMDB-70741, PDB-9oq6: Structure of the human sweet receptor bound to advantame in the loose state, extracellular domain 手法: EM (単粒子) / 解像度: 3.57 Å |
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| 化合物 | |
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| 由来 | homo sapiens (ヒト) mus musculus (ハツカネズミ)
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キーワード | SIGNALING PROTEIN / Membrane protein / GPCR / apo state |
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