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-Structure paper
| Title | Molecular mechanism of allosteric modulation of opioid receptors. |
|---|---|
| Journal, issue, pages | Signal Transduct Target Ther, Vol. 11, Year 2026 |
| Publish date | Oct 29, 2025 |
Authors | Wang, H. / Miao, Z. / Zhao, C. / Fu, H. / Tian, X. / Liu, X. / Wang, L. / Liu, Y. / Yong, X. / Su, L. ...Wang, H. / Miao, Z. / Zhao, C. / Fu, H. / Tian, X. / Liu, X. / Wang, L. / Liu, Y. / Yong, X. / Su, L. / Yan, W. / Cheng, L. / Chai, R. / Shao, Z. / Ke, B. |
External links | Signal Transduct Target Ther / PubMed:42362532 |
| Methods | EM (single particle) |
| Resolution | 2.52 - 3.22 Å |
| Structure data | EMDB-66723, PDB-9xc6: ![]()
EMDB-66725: BMS-986187-bound MOR-Gi1 G Protein EM map ![]()
EMDB-66726: The overall map of BMS-986187-bound MOR-Gi1 complex ![]()
EMDB-66730: The receptor local map of BMS-986187-bound MOR-Gi1 complex EMDB-66771, PDB-9xdq: EMDB-66773, PDB-9xdr: EMDB-66801, PDB-9xf4: ![]()
EMDB-66825: The receptor local map of BMS-986187-bound DOR-Gi2 complex ![]()
EMDB-66826: The G PROTEIN map of BMS-986187-bound DOR-Gi1 complex ![]()
EMDB-66827: The overall map of BMS-986187-bound DOR-Gi2 complex ![]()
EMDB-66828: The receptor local map of asimadoline-BMS-986187-bound KOR-Gi1 complex ![]()
EMDB-66829: The G PROTEIN map of asimadoline-BMS-986187-bound KOR-Gi1 complex ![]()
EMDB-66830: The overall map of asimadoline-BMS-986187-bound KOR-Gi1 complex ![]()
EMDB-66831: The receptor local map of Leu-enkephalin-BMS-986187-bound DOR-Gi complex ![]()
EMDB-66832: The Gi protein local map of Leu-enkephalin-BMS-986187-bound DOR-Gi complex ![]()
EMDB-66833: The overall map of Leu-enkephalin-BMS-986187-bound DOR-Gi complex |
| Chemicals | ![]() PDB-1d6b: ![]() PDB-1esg: ![]() PDB-1e0f: |
| Source |
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Keywords | MEMBRANE PROTEIN / Complex / Agonist / PAM |
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homo sapiens (human)
oplophorus gracilirostris (arthropod)
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