| タイトル | Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop |
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| ジャーナル・号・ページ | Biorxiv, Year 2026 |
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| 掲載日 | 2025年11月10日 (構造データの登録日) |
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著者 | Hay IM / Bourguet M / Ahsan B / Perisic O / Anandapadamanaban M / Williams RL |
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リンク | Biorxiv / PubMedで検索 |
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| 手法 | EM (単粒子) / EM (サブトモグラム平均) |
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| 解像度 | 2.6 - 6.4 Å |
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| 構造データ | EMDB-55637, PDB-9t7j: cryo-EM structure of AKT phosphorylated mTOR complex 2, overall refinement 手法: EM (単粒子) / 解像度: 3.0 Å EMDB-55714, PDB-9t92: cryo-EM structure of autophosphorylated mTOR complex 2, overall refinement 手法: EM (単粒子) / 解像度: 3.1 Å EMDB-55715, PDB-9t93: cryo-EM structure of autophosphorylated mTOR complex 2, focused on a single protomer 手法: EM (単粒子) / 解像度: 2.86 Å EMDB-55716, PDB-9t94: cryo-EM structure of AKT phosphorylated mTOR complex 2, focused on a single protomer 手法: EM (単粒子) / 解像度: 2.6 Å EMDB-55803, PDB-9tds: cryo-EM structure of dephosphorylated mTOR complex 2, overall refinement 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-55804, PDB-9tdt: cryo-EM structure of dephosphorylated mTOR complex 2, focused on a single protomer 手法: EM (単粒子) / 解像度: 3.0 Å EMDB-56117, PDB-9tpw: cryo-ET structure of mTOR complex 2 on a PIP2-containing membrane 手法: EM (サブトモグラム平均) / 解像度: 6.4 Å |
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| 化合物 | ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP, エネルギー貯蔵分子*YM
ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP, エネルギー貯蔵分子*YM
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| 由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / Kinase / Complex / Signaling protein |
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