EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome
ジャーナル・号・ページ	Nature, Year 2026
掲載日	2024年10月24日 (構造データの登録日)
著者	Shi H / Wang X / Yu C / Mao H / Jiao F / Braitbard M / Shor B / Zhang Z / Hinds TR / Cao S ...Shi H / Wang X / Yu C / Mao H / Jiao F / Braitbard M / Shor B / Zhang Z / Hinds TR / Cao S / Fan E / Schneidman-Duhovny D / Huang L / Zheng N
リンク	Nature / PubMedで検索
手法	EM (単粒子)
解像度	2.96 - 4.6 Å
構造データ	EMDB-47500: Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-1 手法: EM (単粒子) / 解像度: 3.2 Å EMDB-47502: Focused map of COP9 signalosome precatalytic state with neddylated cullin-1 手法: EM (単粒子) / 解像度: 3.2 Å 47532 9e5z EMDB-47532, PDB-9e5z: Cryo-EM structure of COP9 signalosome 手法: EM (単粒子) / 解像度: 3.4 Å 47660 9e77 EMDB-47660, PDB-9e77: Cryo-EM structure of CSN-N8 in complex with CSN5i-3 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-47663: Cryo-EM structure of COP9 signalosome deneddylation state with cullin-5 手法: EM (単粒子) / 解像度: 3.5 Å EMDB-47665: Focused map of COP9 signalosome deneddylation state with cullin-5 手法: EM (単粒子) / 解像度: 3.7 Å 47698 9e81 EMDB-47698, PDB-9e81: Cryo-EM structure of COP9 signalosome in complex with CSN5i-3 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-47699: Focused map of COP9 signalosome deneddylation state with cullin-4A 手法: EM (単粒子) / 解像度: 3.5 Å EMDB-47701: Cryo-EM structure of COP9 signalosome deneddylation complex with cullin-2 手法: EM (単粒子) / 解像度: 3.0 Å EMDB-47702: Focused map of COP9 signalosome deneddylation complex with cullin-2 手法: EM (単粒子) / 解像度: 3.0 Å EMDB-47729: Cryo-EM structure of CSN-N8CUL1 complex with CSN5i-3 手法: EM (単粒子) / 解像度: 3.0 Å EMDB-47767: Focused map of CSN-N8CUL1 in complex with CSN5i-3 手法: EM (単粒子) / 解像度: 3.34 Å EMDB-47776: Cryo-EM structure of COP9 signalosome deneddylation complex with cullin-3 手法: EM (単粒子) / 解像度: 3.93 Å 47976 9efm EMDB-47976, PDB-9efm: Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-1 手法: EM (単粒子) / 解像度: 3.16 Å 47977 9efq EMDB-47977, PDB-9efq: Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-2 手法: EM (単粒子) / 解像度: 2.96 Å 47981 9efv EMDB-47981, PDB-9efv: Cryo-EM structure of CSN-N8CUL1 in complex with CSN5i-3 手法: EM (単粒子) / 解像度: 3.03 Å 47983 9eg1 EMDB-47983, PDB-9eg1: COP9 signalosome deneddylation complex with cullin-5 手法: EM (単粒子) / 解像度: 3.52 Å EMDB-47985: Focused map of COP9 signalosome deneddylation complex with neddylated cullin-3 手法: EM (単粒子) / 解像度: 4.6 Å 47986 9eg8 EMDB-47986, PDB-9eg8: Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-4A 手法: EM (単粒子) / 解像度: 3.39 Å 47990 9egl EMDB-47990, PDB-9egl: Cryo-EM structure of COP9 signalosome precatalytic state with neddylated cullin-3 手法: EM (単粒子) / 解像度: 3.93 Å 71639 9ph4 EMDB-71639, PDB-9ph4: Cryo-EM structure of COP9 signalosome in complex with CSN5i-1a 手法: EM (単粒子) / 解像度: 3.0 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-6LT: 3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide PDB-1ch3: RECOMBINANT SPERM WHALE MYOGLOBIN L89W MUTANT (MET)
由来	homo sapiens (ヒト)
キーワード	METAL BINDING PROTEIN / COP9 / COP9 signalosome / signalosome / deneddylation / CSN5 / metalloprotease / SIGNALING PROTEIN / NEDD8 / CSN5i-3 / N8CUL1 / CSN / cullin-2 / CSN-N8CUL2 / CUL2 / othosteric molecular glue / N8CUL5 / CUL5 / N8CUL4A / CUL4A / deneddylation complex / CSN5i-1a