Title | Structural characterization of antibody-responses from Zolgensma treatment guides the design of a capsid suitable for redosing |
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Journal, issue, pages | Nat Commun, Year 2025 |
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Publish date | Mar 25, 2024 (structure data deposition date) |
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Authors | Mietzsch M / Nelson AR / Hsi J / Zachary J / Potts L / Chipman P / Ghanem M / Alexander IE / Logan GJ / Huiskonen J / McKenna R |
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External links | Search PubMed |
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Methods | EM (single particle) |
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Resolution | 2.18 - 3.47 Å |
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Structure data | EMDB-44271, PDB-9b6n: Fab1-1 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 3.31 Å EMDB-44272, PDB-9b6o: Fab1-2 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.61 Å EMDB-44273, PDB-9b6p: Fab1-3 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 3.13 Å EMDB-44274, PDB-9b6q: Fab1-4 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.77 Å EMDB-44275, PDB-9b6r: Fab1-5 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 3.19 Å EMDB-44276, PDB-9b6s: Fab1-6 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 3.47 Å EMDB-44277, PDB-9b6t: Fab1-7 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.54 Å EMDB-44314, PDB-9b7k: Fab2-1 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.75 Å EMDB-44315, PDB-9b7l: Fab2-2 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.82 Å EMDB-44316, PDB-9b7m: Fab2-3 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.82 Å EMDB-44317, PDB-9b7n: Fab2-4 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 3.02 Å EMDB-44318, PDB-9b7o: Fab2-5 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.86 Å EMDB-44319, PDB-9b7p: Fab2-6 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.98 Å EMDB-44320, PDB-9b7q: Fab2-7 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.18 Å EMDB-44325, PDB-9b7v: Fab3-5 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.76 Å EMDB-44326, PDB-9b7w: Fab3-6 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 3.36 Å EMDB-44327, PDB-9b7x: Fab3-7 in complex with the capsid of Adeno-associated virus type 9 Method: EM (single particle) / Resolution: 2.76 Å |
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Chemicals | |
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Source |  adeno-associated virus homo sapiens (human)
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Keywords | VIRAL PROTEIN/IMMUNE SYSTEM / Adeno-associated virus / AAV / capsid / Fab-complex / antibody / NAb / VIRUS / VIRAL PROTEIN-IMMUNE SYSTEM complex |
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