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-Structure paper
Title | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution |
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Journal, issue, pages | To Be Published |
Publish date | May 5, 2023 (structure data deposition date) |
Authors | Huang Y / Kumar S / Lu W / Du J |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 1.97 - 4.14 Å |
Structure data | EMDB-40721, PDB-8sr7: EMDB-40722, PDB-8sr8: EMDB-40723, PDB-8sr9: EMDB-40724, PDB-8sra: EMDB-40725, PDB-8srb: EMDB-40726, PDB-8src: EMDB-40727, PDB-8srd: EMDB-40728, PDB-8sre: EMDB-40729, PDB-8srf: EMDB-40730, PDB-8srg: EMDB-40731, PDB-8srh: EMDB-40732, PDB-8sri: EMDB-40733, PDB-8srj: EMDB-40734, PDB-8srk: EMDB-40865: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme in the presence of Calcium and ADP-ribose EMDB-40866: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate EMDB-40867: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate EMDB-40868: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state EMDB-40869: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state EMDB-40870: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state EMDB-40871: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, open state EMDB-40872: NUDT9-H domain focused cryo-EM map of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, closed state EMDB-40875: Raw consensus map of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate EMDB-40876: Raw consensus map of TRPM2 chanzyme in the presence of Magnesium EMDB-40877: Raw consensus map of TRPM2 chanzyme in the presence of Calcium EMDB-40878: Raw consensus map of TRPM2 chanzyme in the presence of EDTA and ADP-ribose EMDB-40879: Raw consensus map of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state EMDB-40880: Raw consensus map of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state EMDB-40881: Raw consensus map of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state EMDB-40883: Raw consensus map of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate EMDB-40887: Raw consensus map of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, open state EMDB-40888: Raw consensus map of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, closed state EMDB-40893: Raw consensus map of TRPM2 chanzyme in the presence of Calcium and ADP-ribose. EMDB-40895: Raw consensus map of TRPM2 chanzyme in the presence of EDTA (apo state) |
Chemicals | ChemComp-RP5: ChemComp-AMP: ChemComp-MG: ChemComp-CLR: ChemComp-HOH: ChemComp-CA: ChemComp-APR: |
Source |
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Keywords | TRANSPORT PROTEIN / TRPM2 Chanzyme / Channel-enzyme / MEMBRANE PROTEIN |