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| Title | Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis |
|---|---|
| Journal, issue, pages | Nat Commun, Vol. 16, Page 3466, Year 2025 |
| Publish date | Feb 18, 2024 (structure data deposition date) |
Authors | Zhou B / Gao Y / Zhao H / Liu B / Zhang H / Fang C / Yuan H / Wang J / Li Z / Zhao Y ...Zhou B / Gao Y / Zhao H / Liu B / Zhang H / Fang C / Yuan H / Wang J / Li Z / Zhao Y / Huang X / Wang X / Oliveira ASF / Spencer J / Mulholland AJ / Burston SG / Hu J / Su N / Chen X / He J / Zhang T / Xiong X |
External links | Nat Commun / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.2 - 3.69 Å |
| Structure data | EMDB-39157, PDB-8ycx: EMDB-39161, PDB-8yd0: EMDB-39162, PDB-8yd1: EMDB-39163, PDB-8yd2: EMDB-39164, PDB-8yd4: |
| Chemicals | ![]() ChemComp-ADP: ![]() ChemComp-ATP: ![]() ChemComp-MG: ![]() ChemComp-BO2: |
| Source |
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Keywords | HYDROLASE / Mycobacterium tuberculosis / Caseinolytic protease system / Activation / holoenzymes / antibiotics / Bortezomib |
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