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-Structure paper
Title | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain |
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Journal, issue, pages | Nature, Year 2024 |
Publish date | Aug 24, 2023 (structure data deposition date) |
Authors | Kefauver JM / Hakala M / Zou L / Alba J / Espadas J / Tettamanti MG / Gajic J / Gabus C / Campomanes P / Estrozi LF ...Kefauver JM / Hakala M / Zou L / Alba J / Espadas J / Tettamanti MG / Gajic J / Gabus C / Campomanes P / Estrozi LF / Sen NE / Vanni S / Roux A / Desfosses A / Loewith R |
External links | Nature / Search PubMed |
Methods | EM (single particle) / EM (helical sym.) |
Resolution | 3.2 - 3.86 Å |
Structure data | EMDB-18307: Native eisosome lattice bound to plasma membrane microdomain EMDB-18308, PDB-8qb9: EMDB-18309, PDB-8qbb: EMDB-18310, PDB-8qbd: EMDB-18311: Compact state - Native eisosome lattice bound to plasma membrane microdomain EMDB-19822: Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+bromosterol (DOPC, DOPE, DOPS, bromo-ergosterol, PI(4,5)P2 35:20:20:15:10) |
Chemicals | ChemComp-I3P: ChemComp-P5S: ChemComp-SEP: |
Source |
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Keywords | LIPID BINDING PROTEIN / BAR domain / plasma membrane microdomain / membrane curvature / native biochemistry / lipid reconstitution / membrane microdomain |