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-Structure paper
タイトル | Visualizing chaperonin function in situ by cryo-electron tomography |
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ジャーナル・号・ページ | Nature, Year 2024 |
掲載日 | 2023年5月23日 (構造データの登録日) |
著者 | Wagner J / Caravajal AI / Beck F / Bracher A / Wan W / Bohn S / Koerner R / Baumeister W / Fernandez-Busnadiego R / Hartl FU |
リンク | Nature / PubMedで検索 |
手法 | EM (単粒子) / EM (サブトモグラム平均) |
解像度 | 2.5 - 15.2 Å |
構造データ | EMDB-17418, PDB-8p4m: EMDB-17420, PDB-8p4n: EMDB-17421, PDB-8p4o: EMDB-17422: Density for MetK encapsulated in the GroEL7-GroES7 cage EMDB-17423: Symmetry-averaged GroEL7-GroES7 chamber with encapsulated disordered substrate MetK obtained by in vitro cryo electron tomography EMDB-17424: Symmetry-averaged GroEL7-GroES7 chamber with encapsulated ordered substrate MetK obtained by in vitro cryo electron tomography EMDB-17425, PDB-8p4p: EMDB-17426, PDB-8p4r: EMDB-17534: Cryo-EM structure of a D7-symmetrical GroEL14-GroES14 complex in presence of ADP-BeFx EMDB-17535: Cryo-EM structure of a C7-symmetrical GroEL14-GroES7 complex in presence of ADP-BeFx EMDB-17559: In situ structure average of GroEL7-GroES7 chamber with no or disordered substrate in Escherichia coli cytosol obtained by cryo electron tomography EMDB-17560: In situ structure average of GroEL7-GroES7 chamber with encapsulated, ordered substrate in Escherichia coli cytosol obtained by cryo electron tomography EMDB-17561: Cryo-ET subtomogram of 70S ribosomes in Escherichia coli cells at 37 and 46 degrees centigrade and in Escherichia coli cells overexpressing GroELS and MetK EMDB-17562: Cryo-ET subtomogram of 70S ribosomes in Escherichia coli cells overexpressing GroEL EMDB-17563: CryoEM structure of a GroEL14-GroES7 cage with encapsulated ordered substrate MetK in the presence of ADP-BeFx EMDB-17564: CryoEM structure of a GroEL14-GroES7 cage with encapsulated disordered substrate MetK in the presence of ADP-BeFx EMDB-17565: CryoEM structure of a GroEL14-GroES14 cage with two encapsulated disordered MetK substrates in the presence of ADP-BeFx EMDB-17566: CryoEM structure of a (GroEL)14-(GroES)14 complex with encapsulated ordered MetK substrate in one chamber and no or disordered MetK substrate in the other chamber in the presence of ADP-BeFx EMDB-17567: Conformer 1 of the (GroEL)14(GroES)14 complex with two encapsulated, ordered and near-native MetK substrate molecules in the presence of ADP-BeFx EMDB-17568: Conformer 2 of the (GroEL)14(GroES)14 complex with two encapsulated, near-native and ordered MetK substrates in the presence of ADP-BeFx EMDB-17569: Conformer 3 of the (GroEL)14(GroES)14 complex with two encapsulated, near-native and ordered MetK substrates in the presence of ADP-BeFx EMDB-17570: Conformer 4 of the (GroEL)14(GroES)14 complex with two encapsulated, near-native and ordered MetK substrates in the presence of ADP-BeFx EMDB-17571: Conformer 5 of the (GroEL)14(GroES)14 complex with two encapsulated, near-native and ordered MetK substrates in the presence of ADP-BeFx EMDB-17572: Conformer 6 of the (GroEL)14(GroES)14 complex with two encapsulated, near-native and ordered MetK substrates in the presence of ADP-BeFx EMDB-17573: Conformer 7 of the (GroEL)14(GroES)14 complex with two encapsulated, near-native and ordered MetK substrates in the presence of ADP-BeFx EMDB-18735, PDB-8qxs: EMDB-18736, PDB-8qxt: EMDB-18737, PDB-8qxu: EMDB-18738, PDB-8qxv: |
化合物 | ChemComp-ADP: ChemComp-MG: ChemComp-BEF: ChemComp-K: ChemComp-HOH: ChemComp-ATP: |
由来 |
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キーワード | CHAPERONE / Chaperonin / Folding cage / proteostasis / heat shock / ATPase |