EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
ジャーナル・号・ページ	Proc Natl Acad Sci U S A, Vol. 120, Issue 51, Page e2306767120, Year 2023
掲載日	2023年12月19日
著者	Chao Qi / Bert M Verheijen / Yasumasa Kokubo / Yang Shi / Stephan Tetter / Alexey G Murzin / Asa Nakahara / Satoru Morimoto / Marc Vermulst / Ryogen Sasaki / Eleonora Aronica / Yoshifumi Hirokawa / Kiyomitsu Oyanagi / Akiyoshi Kakita / Benjamin Ryskeldi-Falcon / Mari Yoshida / Masato Hasegawa / Sjors H W Scheres / Michel Goedert /
PubMed 要旨	The amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of the island of Guam and the Kii peninsula of Japan is a fatal neurodegenerative disease of unknown cause that is ...The amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of the island of Guam and the Kii peninsula of Japan is a fatal neurodegenerative disease of unknown cause that is characterized by the presence of abundant filamentous tau inclusions in brains and spinal cords. Here, we used electron cryo-microscopy to determine the structures of tau filaments from the cerebral cortex of three cases of ALS/PDC from Guam and eight cases from Kii, as well as from the spinal cord of two of the Guam cases. Tau filaments had the chronic traumatic encephalopathy (CTE) fold, with variable amounts of Type I and Type II filaments. Paired helical tau filaments were also found in three Kii cases and tau filaments with the corticobasal degeneration fold in one Kii case. We identified a new Type III CTE tau filament, where protofilaments pack against each other in an antiparallel fashion. ALS/PDC is the third known tauopathy with CTE-type filaments and abundant tau inclusions in cortical layers II/III, the others being CTE and subacute sclerosing panencephalitis. Because these tauopathies are believed to have environmental causes, our findings support the hypothesis that ALS/PDC is caused by exogenous factors.
リンク	Proc Natl Acad Sci U S A / PubMed:38100415 / PubMed Central
手法	EM (らせん対称)
解像度	2.0 - 3.6 Å
構造データ	17171 8ot6 EMDB-17171, PDB-8ot6: CTE typeI tau filament from Guam ALS/PDC 手法: EM (らせん対称) / 解像度: 2.0 Å 17173 8ot9 EMDB-17173, PDB-8ot9: CTE typeIII tau filament from Guam ALS/PDC 手法: EM (らせん対称) / 解像度: 3.4 Å 17174 8otc EMDB-17174, PDB-8otc: CTE typeII tau filament from Guam ALS/PDC 手法: EM (らせん対称) / 解像度: 3.2 Å 17175 8otd EMDB-17175, PDB-8otd: TMEM106B Fold1-s filament from Guam ALS/PDC 手法: EM (らせん対称) / 解像度: 2.6 Å 17176 8ote EMDB-17176, PDB-8ote: TMEM106B Fold I-d filament from Guam ALS/PDC 手法: EM (らせん対称) / 解像度: 3.6 Å 17177 8otf EMDB-17177, PDB-8otf: Ab typeII filament from Guam ALS/PDC 手法: EM (らせん対称) / 解像度: 3.3 Å 17178 8otg EMDB-17178, PDB-8otg: CTE typeI tau filament from Kii ALS/PDC 手法: EM (らせん対称) / 解像度: 2.1 Å 17179 8oth EMDB-17179, PDB-8oth: TypeII tau filament from Kii ALS/PDC 手法: EM (らせん対称) / 解像度: 3.4 Å 17180 8oti EMDB-17180, PDB-8oti: CTE typeIII tau filament 手法: EM (らせん対称) / 解像度: 2.7 Å 17181 8otj EMDB-17181, PDB-8otj: PHF tau filament from Kii ALS/PDC 手法: EM (らせん対称) / 解像度: 3.3 Å
由来	homo sapiens (ヒト)
キーワード	PROTEIN FIBRIL / Tau filaments / Guam ALS/PDC / CTE typeI / CTE typeIII / CTE typeII / TMEM106B fold1-single filaments / TMEM106B / Ab typeII filaments / Tau filament / Kii ALS/PDC / TypeII tau filaments / PHF