EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
ジャーナル・号・ページ	Sci Rep, Vol. 6, Page 34701-34701, Year 2016
掲載日	2015年9月22日 (構造データの登録日)
著者	Jones, A.M. / Westwood, I.M. / Osborne, J.D. / Matthews, T.P. / Cheeseman, M.D. / Rowlands, M.G. / Jeganathan, F. / Burke, R. / Lee, D. / Kadi, N. ...Jones, A.M. / Westwood, I.M. / Osborne, J.D. / Matthews, T.P. / Cheeseman, M.D. / Rowlands, M.G. / Jeganathan, F. / Burke, R. / Lee, D. / Kadi, N. / Liu, M. / Richards, M. / McAndrew, C. / Yahya, N. / Dobson, S.E. / Jones, K. / Workman, P. / Collins, I. / van Montfort, R.L.
リンク	Sci Rep / PubMed:27708405
手法	X線回折
解像度	1.53 - 2.72 Å
構造データ	PDB-5aqf: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-5aqg: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2.24 Å PDB-5aqh: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5aqi: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-5aqj: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-5aqk: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-5aql: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.69 Å PDB-5aqm: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-5aqn: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-5aqo: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-5aqp: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2.08 Å PDB-5aqq: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å PDB-5aqr: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-5aqs: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5aqt: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5aqu: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-5aqv: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-5aqw: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å PDB-5aqx: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-5aqy: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 手法: X-RAY DIFFRACTION / 解像度: 1.56 Å
化合物	ChemComp-ADN: ADENOSINE / アデノシン ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-TRS: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / トリス(ヒドロキシメチル)メチルアンモニウム / pH緩衝剤YM ChemComp-HOH: WATER ChemComp-ZJB: (2R,3R,4S,5R)-2-(3-AMINO-5-METHYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-1(5H)-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL / トリシリビン ChemComp-CL: Unknown entry / クロリド ChemComp-ZVO: 5-methyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-ADE: ADENINE / アデニン ChemComp-Q88: 9H-purine-6,8-diamine / 8-アミノアデニン ChemComp-GDP: GUANOSINE-5'-DIPHOSPHATE / GDP / GDP, エネルギー貯蔵分子YM ChemComp-JG8: BENZOFURO[3,2-D]PYRIMIDIN-4(3H)-ONE ChemComp-CWS: 6-METHYLQUINAZOLIN-4-AMINE / 6-メチルキナゾリン-4-アミン ChemComp-1LQ: quinazolin-4-amine / キナゾリン-4-アミン ChemComp-BBW: 7-methylquinazolin-4-amine ChemComp-N8Y: 6-methoxyquinazolin-4-amine ChemComp-1SQ: ISOQUINOLIN-1-AMINE / 1-アミノイソキノリン ChemComp-5P7: (1S,2R,3R,5R)-3-(hydroxymethyl)-5-(quinazolin-4-ylamino)cyclopentane-1,2-diol ChemComp-UX0: (1S,2R,3R,5R)-3-(HYDROXYMETHYL)-5-((5-METHOXYQUINAZOLIN-4-YL)AMINO)CYCLOPENTANE-1,2-DIOL ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-KC7: (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-DTV: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL / D-DTT ChemComp-EDO*: 1,2-ETHANEDIOL / エチレングリコ-ル
由来	homo sapiens (ヒト)
キーワード	CHAPERONE / HEAT SHOCK PROTEIN / HSP70 / HSP72 / HSC70 / ATPASE / BAG1 / FRAGMENT