タイトル | Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2015年3月29日 (構造データの登録日) |
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著者 | Laponogov, I. / Veselkov, D.A. / Pan, X.-S. / Selvarajah, J. / Crevel, I.M.-T. / Fisher, L.M. / Sanderson, M.R. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 3.04 - 3.46 Å |
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構造データ | PDB-4z2c: Quinolone(Moxifloxacin)-DNA cleavage complex of gyrase from S. pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 3.19 Å PDB-4z2d: Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 3.38 Å PDB-4z2e: Quinolone(Trovafloxacin)-DNA cleavage complex of gyrase from S. pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 3.46 Å PDB-4z3o: Quinolone(Moxifloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 3.44 Å PDB-4z4q: Quinazolinedione(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 3.04 Å PDB-4z53: Quinolone(Trovafloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 3.26 Å |
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化合物 | ChemComp-MFX: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid / モキシフロキサシン / 抗生剤*YM
ChemComp-LFX: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid / レボフロキサシン / 薬剤, 抗生剤*YM
ChemComp-PDQ: 3-amino-7-{(3R)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methylquinazoline-2,4(1H,3H)-dione
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由来 | - streptococcus pneumoniae (肺炎レンサ球菌)
- escherichia coli (大腸菌)
- streptococcus pneumoniae serotype 4 (strain atcc baa-334 / tigr4) (肺炎レンサ球菌)
- pbr322 based ig-lambda expression vector (その他)
- streptococcus pneumoniae tigr4 (肺炎レンサ球菌)
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キーワード | ISOMERASE / Gyrase / Cleavage complex / DNA / quinolone / Topo IV / Topoisomerase IV |
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