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-Structure paper
タイトル | Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. |
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ジャーナル・号・ページ | Biochem. J., Vol. 454, Page 191-200, Year 2013 |
掲載日 | 2012年4月6日 (構造データの登録日) |
![]() | Stogios, P.J. / Spanogiannopoulos, P. / Evdokimova, E. / Egorova, O. / Shakya, T. / Todorovic, N. / Capretta, A. / Wright, G.D. / Savchenko, A. |
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手法 | X線回折 |
解像度 | 1.863 - 2.71 Å |
構造データ | ![]() PDB-4ej7: ![]() PDB-4feu: ![]() PDB-4fev: ![]() PDB-4few: ![]() PDB-4fex: ![]() PDB-4gkh: ![]() PDB-4gki: |
化合物 | ![]() ChemComp-ATP: ![]() ChemComp-CA: ![]() ChemComp-PEG: ![]() ChemComp-HOH: ![]() ChemComp-KAN: ![]() ChemComp-537: ![]() ChemComp-ACT: ![]() ChemComp-PP1: ![]() ChemComp-NA: ![]() ChemComp-PP2: ![]() ChemComp-CL: ![]() ChemComp-0TO: ![]() ChemComp-0J9: ![]() ChemComp-0JN: |
由来 |
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![]() | TRANSFERASE / CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES / CSGID / NIAID / National Institute of Allergy and Infectious Diseases / EUKARYOTIC PROTEIN KINASE-LIKE FOLD / ALPHA/BETA PROTEIN / PHOSPHOTRANSFERASE / AMINOGLYCOSIDE PHOSPHOTRANSFERASE / ANTIBIOTIC RESISTANCE / AMINOGLYCOSIDES / KANAMYCIN / GTP / INTRACELLULAR / TRANSFERASE/TRANSFERASE INHIBITOR / anthrapyrazolone / SP600125 / protein kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex / pyrazolopyrimidine / PP1 / PP2 / tyrphostin / 4-anilinoquinazoline / tyrphostin AG1478 / AG1478 / 1-NA-PP1 / BUMPED KINASE INHIBITOR / BKI / 1-NM-PP1 |