EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
ジャーナル・号・ページ	Biochem. J., Vol. 454, Page 191-200, Year 2013
掲載日	2012年4月6日 (構造データの登録日)
著者	Stogios, P.J. / Spanogiannopoulos, P. / Evdokimova, E. / Egorova, O. / Shakya, T. / Todorovic, N. / Capretta, A. / Wright, G.D. / Savchenko, A.
リンク	Biochem. J. / PubMed:23758273
手法	X線回折
解像度	1.863 - 2.71 Å
構造データ	PDB-4ej7: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound 手法: X-RAY DIFFRACTION / 解像度: 2.29 Å PDB-4feu: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor anthrapyrazolone SP600125 手法: X-RAY DIFFRACTION / 解像度: 2.37 Å PDB-4fev: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-4few: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-4fex: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478 手法: X-RAY DIFFRACTION / 解像度: 2.71 Å PDB-4gkh: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1 手法: X-RAY DIFFRACTION / 解像度: 1.863 Å PDB-4gki: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NM-PP1 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å
化合物	ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP, エネルギー貯蔵分子YM ChemComp-CA: Unknown entry ChemComp-PEG: DI(HYDROXYETHYL)ETHER ChemComp-HOH: WATER ChemComp-KAN: KANAMYCIN A / 抗生剤YM ChemComp-537: 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE / 阻害剤YM ChemComp-ACT: ACETATE ION ChemComp-PP1: 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE ChemComp-NA: Unknown entry ChemComp-PP2: 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE ChemComp-CL: Unknown entry ChemComp-0TO: N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine ChemComp-0J9: 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine ChemComp-0JN*: 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
由来	acinetobacter baumannii (バクテリア)
キーワード	TRANSFERASE / CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES / CSGID / NIAID / National Institute of Allergy and Infectious Diseases / EUKARYOTIC PROTEIN KINASE-LIKE FOLD / ALPHA/BETA PROTEIN / PHOSPHOTRANSFERASE / AMINOGLYCOSIDE PHOSPHOTRANSFERASE / ANTIBIOTIC RESISTANCE / AMINOGLYCOSIDES / KANAMYCIN / GTP / INTRACELLULAR / TRANSFERASE/TRANSFERASE INHIBITOR / anthrapyrazolone / SP600125 / protein kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex / pyrazolopyrimidine / PP1 / PP2 / tyrphostin / 4-anilinoquinazoline / tyrphostin AG1478 / AG1478 / 1-NA-PP1 / BUMPED KINASE INHIBITOR / BKI / 1-NM-PP1