EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Design of potent selective zinc-mediated serine protease inhibitors.
ジャーナル・号・ページ	Nature, Vol. 391, Page 608-612, Year 1998
掲載日	1999年7月21日 (構造データの登録日)
著者	Katz, B.A. / Clark, J.M. / Finer-Moore, J.S. / Jenkins, T.E. / Johnson, C.R. / Ross, M.J. / Luong, C. / Moore, W.R. / Stroud, R.M.
リンク	Nature / PubMed:9468142
手法	X線回折
解像度	1.37 - 2.2 Å
構造データ	PDB-1c1n: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-1c1o: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-1c1p: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1c1q: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1c1r: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1c1t: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1c1u: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-1c1v: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-1c1w: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1c2d: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-1c2e: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-1c2f: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-1c2g: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-1c2h: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-1c2i: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-1c2j: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-1c2k: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-1c2l: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-1c2m: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-1xuf: TRYPSIN-BABIM-ZN+2, PH 8.2 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1xug: TRYPSIN-BABIM-ZN+2, PH 8.2 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-1xuh: TRYPSIN-KETO-BABIM-CO+2, PH 8.2 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1xui: TRYPSIN-KETO-BABIM, ZN+2-FREE, PH 8.2 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-1xuj: TRYPSIN-KETO-BABIM-ZN+2, PH 8.2 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-1xuk: TRYPSIN-BABIM-SULFATE, PH 5.9 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
化合物	ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-ZN: Unknown entry ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-BEN: BENZAMIDINE / ベンズアミジン ChemComp-HOH: WATER ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-BAI: (5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE / 2-(1H-ベンゾイミダゾ-ル-2-イルメチル)-6-アミジノ-1H-ベンゾイミダゾ-ル ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-BAB: BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANE ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-BAH: BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE HYDRATE ChemComp-BAK: BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE ChemComp-CL: Unknown entry / クロリド ChemComp-ABI: 5-AMIDINO-BENZIMIDAZOLE ChemComp-BAZ: BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANE ZINC ChemComp-CO: Unknown entry ChemComp-BAO: BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANONE / ビス(5-アミジノ-1H-ベンゾイミダゾ-ル-2-イル)ケトン ChemComp-BOZ*: BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANONE ZINC
由来	bos taurus (ウシ) homo sapiens (ヒト) hirudo medicinalis (医用ビル)
キーワード	HYDROLASE/HYDROLASE INHIBITOR / ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS / PH DEPENDENCE / ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN / SERINE PROTEASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / SERINE PROTEASE SERINE PROTEASE/INHIBITOR / SERINE PROTEASE/INHIBITOR / BLOOD CLOTTING/HYDROLASE INHIBITOR / BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX / BLOOD CLOTTING / COMPLEX / TRYPSIN-ZN+2-SMALL MOLECULE LIGAND / DESIGNED SMALL MOLECULE LIGAND WITH NANOMOLAR AFFINITY / TRYPSIN-COBALT-SMALL MOLECULE LIGAND / DESIGNED SMALL MOLECULE LIGAND WITH MICROMOLAR AFFINITY / TRYPSIN-SMALL MOLECULE LIGAND / TRYPSIN-SULFATE-SMALL MOLECULE LIGAND