タイトル | CryoEM architecture of a native stretch-sensitive membrane microdomain |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2023年8月24日 (構造データの登録日) |
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著者 | Kefauver JM / Hakala M / Zou L / Alba J / Espadas Moreno J / Tettamanti MG / Estrozi L / Vanni S / Roux A / Desfosses A / Loewith R |
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リンク | To Be Published / PubMedで検索 |
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手法 | EM (単粒子) / EM (らせん対称) |
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解像度 | 3.1 - 3.86 Å |
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構造データ | EMDB-18307: Native eisosome lattice bound to plasma membrane microdomain PDB-8qb7: Pil1 in native eisosome lattice bound to plasma membrane microdomain PDB-8qb8: Lsp1 in native eisosome lattice bound to plasma membrane microdomain 手法: EM (単粒子) / 解像度: 3.2 Å EMDB-18308, PDB-8qb9: Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture -PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol 30:20:20:30) 手法: EM (らせん対称) / 解像度: 3.35 Å EMDB-18309, PDB-8qbb: Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/-sterol (DOPC, DOPE, DOPS, PI(4,5)P2 50:20:20:10) 手法: EM (らせん対称) / 解像度: 3.86 Å EMDB-18310, PDB-8qbd: Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10) 手法: EM (らせん対称) / 解像度: 3.61 Å EMDB-18311: Compact state - Native eisosome lattice bound to plasma membrane microdomain PDB-8qbe: Compact state - Pil1 in native eisosome lattice bound to plasma membrane microdomain PDB-8qbf: Compact state - Pil1 dimer with lipid headgroups fitted in native eisosome lattice bound to plasma membrane microdomain 手法: EM (単粒子) / 解像度: 3.67 Å EMDB-18312: Stretched state - Native eisosome lattice bound to plasma membrane microdomain PDB-8qbg: Stretched state - Pil1 in native eisosome lattice bound to plasma membrane microdomain 手法: EM (単粒子) / 解像度: 3.64 Å EMDB-18822, PDB-8r1l: Structure of avian H5N1 influenza A polymerase in complex with human ANP32B. 手法: EM (単粒子) / 解像度: 3.1 Å |
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化合物 | |
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由来 | ![](img/tx_yeast.gif) saccharomyces cerevisiae (パン酵母)![](img/tx_virus.gif) influenza a virus (A型インフルエンザウイルス) homo sapiens (ヒト)
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キーワード | LIPID BINDING PROTEIN / BAR domain / plasma membrane microdomain / membrane curvature / native biochemistry / lipid reconstitution / membrane microdomain / VIRAL PROTEIN / Influenza virus / replication platform / H5N1 / influenza adaptive mutations / host adaptation / viral polymerase / cryo-EM / HPAI. |
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