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-Structure paper
タイトル | Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. |
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ジャーナル・号・ページ | Science, Vol. 364, Issue 6440, Page 552-557, Year 2019 |
掲載日 | 2019年5月10日 |
著者 | Shoji Maeda / Qianhui Qu / Michael J Robertson / Georgios Skiniotis / Brian K Kobilka / |
PubMed 要旨 | Muscarinic acetylcholine receptors are G protein-coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. There are five muscarinic receptor subtypes ...Muscarinic acetylcholine receptors are G protein-coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. There are five muscarinic receptor subtypes (M1R to M5R), which, despite sharing a high degree of sequence identity in the transmembrane region, couple to different heterotrimeric GTP-binding proteins (G proteins) to transmit signals. M1R, M3R, and M5R couple to the G family, whereas M2R and M4R couple to the G family. Here, we present and compare the cryo-electron microscopy structures of M1R in complex with G and M2R in complex with G The M1R-G complex exhibits distinct features, including an extended transmembrane helix 5 and carboxyl-terminal receptor tail that interacts with G protein. Detailed analysis of these structures provides a framework for understanding the molecular determinants of G-protein coupling selectivity. |
リンク | Science / PubMed:31073061 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.3 - 3.6 Å |
構造データ | EMDB-20078, PDB-6oij: EMDB-20079, PDB-6oik: |
化合物 | ChemComp-IXO: ChemComp-Y01: ChemComp-2CU: |
由来 |
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キーワード | SIGNALING PROTEIN / G-protein coupled receptor-G-protein complex / neurotransmitter receptor |