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TitleStructural basis of odor sensing by insect heteromeric odorant receptors.
Journal, issue, pagesScience, Page eadn6384, Year 2024
Publish dateJun 13, 2024
AuthorsJiawei Zhao / Andy Q Chen / Jaewook Ryu / Josefina Del Mármol /
PubMed AbstractMost insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor ...Most insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo-electron microscopy (cryo-EM) structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos or . These structures reveal an unexpected stoichiometry of 1 OR to 3 Orco subunits. Comparison of structures in odorant-bound and unbound states indicates that odorant binding to the sole OR subunit is sufficient to open the channel pore, suggesting a mechanism of OR activation and a conceptual framework for understanding evolution of insect odorant receptor sensitivity.
External linksScience / PubMed:38870275
MethodsEM (single particle)
Resolution2.62 - 2.95 Å
Structure data

42848

8v00

EMDB-42848, PDB-8v00:
AaegOR10 apo structure
Method: EM (single particle) / Resolution: 2.88 Å

42850

8v02

EMDB-42850, PDB-8v02:
AaegOR10 structure bound to o-cresol
Method: EM (single particle) / Resolution: 2.9 Å

42945

8v3c

EMDB-42945, PDB-8v3c:
AgamOR28 structure without ligand
Method: EM (single particle) / Resolution: 2.62 Å

42946

8v3d

EMDB-42946, PDB-8v3d:
AgamOR28 structure bound to 2,4,5-trimethylthiazole
Method: EM (single particle) / Resolution: 2.95 Å

Chemicals

ChemComp-JZ0:
o-cresol

PDB-1afc:
STRUCTURAL STUDIES OF THE BINDING OF THE ANTI-ULCER DRUG SUCROSE OCTASULFATE TO ACIDIC FIBROBLAST GROWTH FACTOR

Source
  • aedes aegypti (yellow fever mosquito)
  • apocrypta bakeri (insect)
  • anopheles gambiae (African malaria mosquito)
KeywordsMEMBRANE PROTEIN / Mosquito olfactory receptor / Mosquito olfactory receptor OR10 / Mosquitoes / Olfaction / Channel / Heterotetramer

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