Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Journal, issue, pages	Proc Natl Acad Sci U S A, Vol. 120, Issue 51, Page e2306767120, Year 2023
Publish date	Dec 19, 2023
Authors	Chao Qi / Bert M Verheijen / Yasumasa Kokubo / Yang Shi / Stephan Tetter / Alexey G Murzin / Asa Nakahara / Satoru Morimoto / Marc Vermulst / Ryogen Sasaki / Eleonora Aronica / Yoshifumi Hirokawa / Kiyomitsu Oyanagi / Akiyoshi Kakita / Benjamin Ryskeldi-Falcon / Mari Yoshida / Masato Hasegawa / Sjors H W Scheres / Michel Goedert /
PubMed Abstract	The amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of the island of Guam and the Kii peninsula of Japan is a fatal neurodegenerative disease of unknown cause that is ...The amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of the island of Guam and the Kii peninsula of Japan is a fatal neurodegenerative disease of unknown cause that is characterized by the presence of abundant filamentous tau inclusions in brains and spinal cords. Here, we used electron cryo-microscopy to determine the structures of tau filaments from the cerebral cortex of three cases of ALS/PDC from Guam and eight cases from Kii, as well as from the spinal cord of two of the Guam cases. Tau filaments had the chronic traumatic encephalopathy (CTE) fold, with variable amounts of Type I and Type II filaments. Paired helical tau filaments were also found in three Kii cases and tau filaments with the corticobasal degeneration fold in one Kii case. We identified a new Type III CTE tau filament, where protofilaments pack against each other in an antiparallel fashion. ALS/PDC is the third known tauopathy with CTE-type filaments and abundant tau inclusions in cortical layers II/III, the others being CTE and subacute sclerosing panencephalitis. Because these tauopathies are believed to have environmental causes, our findings support the hypothesis that ALS/PDC is caused by exogenous factors.
External links	Proc Natl Acad Sci U S A / PubMed:38100415 / PubMed Central
Methods	EM (helical sym.)
Resolution	2.0 - 3.6 Å
Structure data	17171 8ot6 EMDB-17171, PDB-8ot6: CTE typeI tau filament from Guam ALS/PDC Method: EM (helical sym.) / Resolution: 2.0 Å 17173 8ot9 EMDB-17173, PDB-8ot9: CTE typeIII tau filament from Guam ALS/PDC Method: EM (helical sym.) / Resolution: 3.4 Å 17174 8otc EMDB-17174, PDB-8otc: CTE typeII tau filament from Guam ALS/PDC Method: EM (helical sym.) / Resolution: 3.2 Å 17175 8otd EMDB-17175, PDB-8otd: TMEM106B Fold1-s filament from Guam ALS/PDC Method: EM (helical sym.) / Resolution: 2.6 Å 17176 8ote EMDB-17176, PDB-8ote: TMEM106B Fold I-d filament from Guam ALS/PDC Method: EM (helical sym.) / Resolution: 3.6 Å 17177 8otf EMDB-17177, PDB-8otf: Ab typeII filament from Guam ALS/PDC Method: EM (helical sym.) / Resolution: 3.3 Å 17178 8otg EMDB-17178, PDB-8otg: CTE typeI tau filament from Kii ALS/PDC Method: EM (helical sym.) / Resolution: 2.1 Å 17179 8oth EMDB-17179, PDB-8oth: TypeII tau filament from Kii ALS/PDC Method: EM (helical sym.) / Resolution: 3.4 Å 17180 8oti EMDB-17180, PDB-8oti: CTE typeIII tau filament Method: EM (helical sym.) / Resolution: 2.7 Å 17181 8otj EMDB-17181, PDB-8otj: PHF tau filament from Kii ALS/PDC Method: EM (helical sym.) / Resolution: 3.3 Å
Source	homo sapiens (human)
Keywords	PROTEIN FIBRIL / Tau filaments / Guam ALS/PDC / CTE typeI / CTE typeIII / CTE typeII / TMEM106B fold1-single filaments / TMEM106B / Ab typeII filaments / Tau filament / Kii ALS/PDC / TypeII tau filaments / PHF