Title | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants |
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Journal, issue, pages | To Be Published |
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Publish date | Jun 6, 2023 (structure data deposition date) |
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Authors | Fibriansah G / Ng TS / Lim XN / Shebanova A / Ng LC / Tan SL / Tan AWK / Shi J / Crowe JE / Lok SM |
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External links | Search PubMed |
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Methods | EM (single particle) / EM (helical sym.) |
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Resolution | 3.3 - 11.0 Å |
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Structure data | EMDB-36429, PDB-8jn1: Cryo-EM structure of dengue virus serotype 3 strain EHIE46200Y19 in complex with human antibody DENV-115 IgG at 4 deg C (subparticle LLR-LRR) Method: EM (single particle) / Resolution: 3.5 Å EMDB-36430, PDB-8jn2: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 4 deg C (subparticle LLR-LRR) Method: EM (single particle) / Resolution: 4.1 Å EMDB-36431, PDB-8jn3: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 37 deg C (subparticle LLR-LRR) Method: EM (single particle) / Resolution: 5.4 Å EMDB-36432, PDB-8jn4: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 4 deg C (subparticle LLR-LRR) Method: EM (single particle) / Resolution: 3.5 Å EMDB-36433, PDB-8jn5: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 37 deg C (subparticle LLR-LRR) Method: EM (single particle) / Resolution: 3.6 Å EMDB-36434, PDB-8jn6: Cryo-EM structure of the small tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C Method: EM (helical sym.) / Resolution: 9.8 Å EMDB-36435, PDB-8jn7: Cryo-EM structure of the big tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C Method: EM (helical sym.) / Resolution: 11.0 Å EMDB-36436: Cryo-EM structure of dengue virus serotype 3 strain EHIE46200Y19 in complex with human antibody DENV-115 IgG at 4 deg C Method: EM (single particle) / Resolution: 3.3 Å EMDB-36437: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 4 deg C Method: EM (single particle) / Resolution: 3.9 Å EMDB-36438: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 37 deg C Method: EM (single particle) / Resolution: 4.1 Å EMDB-36439: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 4 deg C Method: EM (single particle) / Resolution: 3.5 Å EMDB-36440: Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 37 deg C Method: EM (single particle) / Resolution: 3.7 Å EMDB-36441: Cryo-EM structure of dengue virus serotype 3 strain CH53489 spherical particle in complex with human antibody DENV-290 Fab at 37 deg C Method: EM (single particle) / Resolution: 5.6 Å |
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Source | - Aedes albopictus (Asian tiger mosquito)
- homo sapiens (human)
- dengue virus type 3
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Keywords | VIRUS / dengue virus / human antibody / dengue-antibody structure / VIRUS/IMMUNE SYSTEM / VIRUS-IMMUNE SYSTEM complex |
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