Title | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis |
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Journal, issue, pages | To Be Published |
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Publish date | Jul 23, 2023 (structure data deposition date) |
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Authors | Cogan DP / Soohoo AM / Chen M / Liu Y / Brodsky KL / Khosla C |
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External links | Search PubMed |
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Methods | EM (single particle) |
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Resolution | 3.05 - 3.73 Å |
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Structure data | EMDB-41305, PDB-8tjn: Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 Method: EM (single particle) / Resolution: 3.73 Å EMDB-41306, PDB-8tjo: Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked Intra-State 1 Method: EM (single particle) / Resolution: 3.61 Å EMDB-41307, PDB-8tjp: KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its elongation ACP partner Method: EM (single particle) / Resolution: 3.71 Å EMDB-41355, PDB-8tko: KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its translocation ACP partner of Module 2 Method: EM (single particle) / Resolution: 3.05 Å EMDB-41495, PDB-8tpw: Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP Method: EM (single particle) / Resolution: 3.46 Å EMDB-41496, PDB-8tpx: Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP Method: EM (single particle) / Resolution: 3.4 Å |
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Source | - saccharopolyspora erythraea (bacteria)
- homo sapiens (human)
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Keywords | BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM / polyketide synthase / antibody / BIOSYNTHETIC PROTEIN-IMMUNE SYSTEM complex / BIOSYNTHETIC PROTEIN |
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