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Structure paper

TitleAntibody-like recognition of a γδ T cell receptor toward a foreign antigen.
Journal, issue, pagesStructure, Vol. 33, Issue 10, Page 1649-11662.e5, Year 2025
Publish dateOct 2, 2025
AuthorsLiam Rashleigh / Hariprasad Venugopal / Michael T Rice / Sachith D Gunasinghe / Chhon Ling Sok / Nicholas A Gherardin / Catarina F Almeida / Ildiko Van Rhijn / D Branch Moody / Dale I Godfrey / Jamie Rossjohn / Benjamin S Gully /
PubMed AbstractThe antigen recognition principles of B cells and αβ T cells have been well described compared to those of the γδ T cell. By way of their specificity conferring receptor (γδTCR), γδ T cells ...The antigen recognition principles of B cells and αβ T cells have been well described compared to those of the γδ T cell. By way of their specificity conferring receptor (γδTCR), γδ T cells can directly bind proteinaceous antigens. A known γδ T cell and B cell model antigen is phycoerythrin (PE), a light harvesting protein from rhodophytes and cyanobacteria. Here we probed human γδTCR reactivity to PE, in which a Vδ1Vγ5 TCR bound directly to induce proximal signaling and cellular activation. We determined the cryoelectron microscopy (cryo-EM) structure of the γδTCR-phycoerythrin immune complex. We then determined the cryo-EM structures of an antibody fragment and an αβTCR bound to PE. This revealed convergent use of apical aromatic residues to mediate contacts with a common PE epitope. Comparative analyses of the γδTCR revealed multiple antibody-like characteristics, including an enrichment of apical aromatic residues. Our findings reveal further distinct facets of antigen recognition by the γδTCR.
External linksStructure / PubMed:40744007
MethodsEM (single particle)
Resolution1.68 - 3.21 Å
Structure data

48248

9mgb

EMDB-48248, PDB-9mgb:
scFv antibody CL33 bound to R-phycoerythrin
Method: EM (single particle) / Resolution: 2.1 Å

48332

9mko

EMDB-48332, PDB-9mko:
4D4 TCR bound to R-phycoerythrin
Method: EM (single particle) / Resolution: 3.21 Å

EMDB-70139: Phycoerythrin bound by 1C5H TCR (complex consensus map)
Method: EM (single particle) / Resolution: 2.03 Å

70155

9o60

EMDB-70155, PDB-9o60:
Local refinement of 1C5H TCR bound to R-phycoerythrin (gamma chain dimer)
Method: EM (single particle) / Resolution: 2.63 Å

70156

9o61

EMDB-70156: 1C5H TCR bound to R-phycoerythrin
PDB-9o61: R-phycoerythrin
Method: EM (single particle) / Resolution: 1.68 Å

70157

9o62

EMDB-70157, PDB-9o62:
1C5H TCR bound to R-phycoerythrin
Method: EM (single particle) / Resolution: 2.03 Å

Chemicals

ChemComp-PEB:
PHYCOERYTHROBILIN

ChemComp-PUB:
PHYCOUROBILIN

Source
  • neopyropia tenera (asakusa nori)
  • mus musculus (house mouse)
  • ceramium secundatum (eukaryote)
  • homo sapiens (human)
  • pyropia tenera (asakusa nori)
KeywordsIMMUNE SYSTEM / Phycoerythrin / antibody / scFv / immunity / TCR / direct recognition / T-cell / gamma delta TCR / direct

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