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TitleCryo-EM structures of tau filaments from Alzheimer's disease.
Journal, issue, pagesNature, Vol. 547, Issue 7662, Page 185-190, Year 2017
Publish dateJul 13, 2017
AuthorsAnthony W P Fitzpatrick / Benjamin Falcon / Shaoda He / Alexey G Murzin / Garib Murshudov / Holly J Garringer / R Anthony Crowther / Bernardino Ghetti / Michel Goedert / Sjors H W Scheres /
PubMed AbstractAlzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic ...Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau filaments with different morphologies characterize other neurodegenerative diseases. No high-resolution structures of tau filaments are available. Here we present cryo-electron microscopy (cryo-EM) maps at 3.4-3.5 Å resolution and corresponding atomic models of paired helical and straight filaments from the brain of an individual with Alzheimer's disease. Filament cores are made of two identical protofilaments comprising residues 306-378 of tau protein, which adopt a combined cross-β/β-helix structure and define the seed for tau aggregation. Paired helical and straight filaments differ in their inter-protofilament packing, showing that they are ultrastructural polymorphs. These findings demonstrate that cryo-EM allows atomic characterization of amyloid filaments from patient-derived material, and pave the way for investigation of a range of neurodegenerative diseases.
External linksNature / PubMed:28678775 / PubMed Central
MethodsEM (helical sym.)
Resolution3.4 - 4.9 Å
Structure data

3741

5o3l

EMDB-3741, PDB-5o3l:
Paired helical filament in Alzheimer's disease brain
Method: EM (helical sym.) / Resolution: 3.4 Å

3742

5o3o

EMDB-3742, PDB-5o3o:
Pronase-treated paired helical filament in Alzheimer's disease brain
Method: EM (helical sym.) / Resolution: 3.5 Å

3743

5o3t

EMDB-3743, PDB-5o3t:
Straight filament in Alzheimer's disease brain
Method: EM (helical sym.) / Resolution: 3.4 Å

EMDB-3744:
Pronase-treated straight filament in Alzheimer's disease brain
Method: EM (helical sym.) / Resolution: 4.9 Å

Source
  • homo sapiens (human)
  • Human (human)
KeywordsSTRUCTURAL PROTEIN / TAU / AMYLOID / CROSS-BETA / BETA-HELIX / PROTEIN FIBRIL

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