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Structure paper

TitleImpact of cytosine methylation on DNA binding specificities of human transcription factors.
Journal, issue, pagesScience, Vol. 356, Year 2017
Publish dateOct 23, 2015 (structure data deposition date)
AuthorsYin, Y. / Morgunova, E. / Jolma, A. / Kaasinen, E. / Sahu, B. / Khund-Sayeed, S. / Das, P.K. / Kivioja, T. / Dave, K. / Zhong, F. ...Yin, Y. / Morgunova, E. / Jolma, A. / Kaasinen, E. / Sahu, B. / Khund-Sayeed, S. / Das, P.K. / Kivioja, T. / Dave, K. / Zhong, F. / Nitta, K.R. / Taipale, M. / Popov, A. / Ginno, P.A. / Domcke, S. / Yan, J. / Schubeler, D. / Vinson, C. / Taipale, J.
External linksScience / PubMed:28473536
MethodsX-ray diffraction
Resolution2.54 - 3.23 Å
Structure data

PDB-5ef6:
Structure of HOXB13 complex with methylated DNA
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-5ego:
HOXB13-MEIS1 heterodimer bound to methylated DNA
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

PDB-5hod:
Structure of LHX4 transcription factor complexed with DNA
Method: X-RAY DIFFRACTION / Resolution: 2.682 Å

PDB-5lty:
Homeobox transcription factor CDX2 bound to methylated DNA
Method: X-RAY DIFFRACTION / Resolution: 2.66 Å

PDB-5lux:
Homeobox transcription factor CDX1 bound to methylated DNA
Method: X-RAY DIFFRACTION / Resolution: 3.23 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / transcription factor / methylated DNA / complex / heterodimer / bound to DNA / Complex with DNA / Dimer

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