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Showing 1 - 50 of 51 items for (author: pike & acw)

EMDB-56750: 
MBP bound to distal DARPin (AHIR dodecamer scaffold system)
Method: single particle / : Ferreira DSM, Noble M, Rowland RJ, Fairhead M, Gittins O, von Delft F, Endicott J, Pike ACW, Sauer DB, Martin M, Dlamini LS

EMDB-56751: 
MBP-maltose bound to distal DARPin (AHIR dodecamer scaffold system)
Method: single particle / : Ferreira DSM, Noble M, Rowland RJ, Fairhead M, Gittins O, von Delft F, Endicott J, Martin M, Pike ACW, Sauer DB, Dlamini LS

EMDB-50668: 
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the apo inward-open state
Method: single particle / : Ye M, Zhou D, Pike ACW, Wang S, Wang D, Bakshi S, Brooke L, Williams E, Elkins J, Stuart DI, Sauer DB

EMDB-50669: 
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the arginine-bound inward-occluded state
Method: single particle / : Ye M, Zhou D, Pike ACW, Wang S, Wang D, Bakshi S, Brooke L, Williams E, Elkins J, Stuart DI, Sauer DB

EMDB-50670: 
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the lysine-bound inward-occluded state
Method: single particle / : Ye M, Zhou D, Pike ACW, Wang S, Wang D, Bakshi S, Brooke L, Williams E, Elkins J, Stuart DI, Sauer DB

EMDB-50671: 
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the ornithine-bound inward-occluded state
Method: single particle / : Ye M, Zhou D, Pike ACW, Wang S, Wang D, Bakshi S, Brooke L, Williams E, Elkins J, Stuart DI, Sauer DB

EMDB-51568: 
Human adult muscle nAChR in resting state in detergent with alpha-bungarotoxin
Method: single particle / : Li A, Pike ACW, Chi G, Webster R, Maxwell S, Liu W, Beeson D, Sauer DB, Dong YY

EMDB-51569: 
Human adult muscle nAChR in resting state in nanodisc with alpha-bungarotoxin
Method: single particle / : Li A, Pike ACW, Chi G, Webster R, Maxwell S, Liu W, Beeson D, Sauer DB, Dong YY

EMDB-51570: 
Human adult muscle nAChR in desensitised state in nanodisc with 100 uM acetylcholine
Method: single particle / : Li A, Pike ACW, Chi G, Webster R, Maxwell S, Liu W, Beeson D, Sauer DB, Dong YY

EMDB-51571: 
Human adult muscle nAChR in desensitised state in nanodisc with 1 mM acetylcholine
Method: single particle / : Li A, Pike ACW, Chi G, Webster R, Maxwell S, Liu W, Beeson D, Sauer DB, Dong YY

EMDB-51335: 
Cryo-EM structure of KBTBD4 WT-HDAC2 2:1 complex mediated by molecular glue UM171
Method: single particle / : Chen Z, Chi G, Pike ACW, Montes B, Bullock AN

EMDB-51336: 
Cryo-EM map of KBTBD4 WT-HDAC2-CoREST1 2:1:1 complex mediated by molecular glue UM171
Method: single particle / : Chen Z, Chi G, Pike ACW, Montes B, Bullock AN

EMDB-51337: 
Cryo-EM structure of KBTBD4 P313PRR mutant-HDAC2 2:2 complex
Method: single particle / : Chen Z, Chi G, Pike ACW, Montes B, Bullock AN

EMDB-51338: 
Cryo-EM structure of KBTBD4 WT-HDAC2 2:2 complex mediated by molecular glue UM171
Method: single particle / : Chen Z, Chi G, Pike ACW, Montes B, Bullock AN

EMDB-18667: 
Structure of human SPNS2 in LMNG
Method: single particle / : Li HZ, Pike ACW, McKinley G, Mukhopadhyay SMM, Moreau C, Scacioc A, Abrusci P, Borkowska O, Chalk R, Stefanic S, Burgess-Brown N, Duerr KL, Sauer DB

EMDB-18668: 
Structure of human SPNS2 in DDM
Method: single particle / : Li HZ, Pike ACW, McKinley G, Mukhopadhyay SMM, Moreau C, Scacioc A, Abrusci P, Borkowska O, Chalk R, Stefanic S, Burgess-Brown N, Duerr KL, Sauer DB

EMDB-18770: 
Structure of human ceramide synthase 6 (CerS6) bound to C16:0
Method: single particle / : Pascoa TC, Pike ACW, Chi G, Stefanic S, Quigley A, Chalk R, Mukhopadhyay SMM, Venkaya S, Dix C, Moreira T, Tessitore A, Cole V, Chu A, Elkins JM, Pautsch A, Schnapp G, Carpenter EP, Sauer DB

EMDB-18771: 
Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1
Method: single particle / : Pascoa TC, Pike ACW, Chi G, Stefanic S, Quigley A, Chalk R, Mukhopadhyay SMM, Venkaya S, Dix C, Moreira T, Tessitore A, Cole V, Chu A, Elkins JM, Pautsch A, Schnapp G, Carpenter EP, Sauer DB

EMDB-19869: 
Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02)
Method: single particle / : Pascoa TC, Pike ACW, Chi G, Stefanic S, Quigley A, Chalk R, Mukhopadhyay SMM, Venkaya S, Dix C, Moreira T, Tessitore A, Cole V, Chu A, Elkins JM, Pautsch A, Schnapp G, Carpenter EP, Sauer DB

EMDB-17377: 
Structure of human SIT1 (focussed map / refinement)
Method: single particle / : Li HZ, Pike ACW, Chi G, Hansen JS, Lee SG, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Chalk R, Moreira T, MacLean EM, Marsden B, Bountra C, Burgess-Brown NA, Dafforn TR, Carpenter EP, Sauer DB

EMDB-17378: 
Structure of human SIT1:ACE2 complex (open PD conformation)
Method: single particle / : Li HZ, Pike ACW, Chi G, Hansen JS, Lee SG, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Chalk R, Moreira T, MacLean EM, Marsden B, Bountra C, Burgess-Brown NA, Dafforn TR, Carpenter EP, Sauer DB

EMDB-17379: 
Structure of human SIT1:ACE2 complex (closed PD conformation)
Method: single particle / : Li HZ, Pike ACW, Chi G, Hansen JS, Lee SG, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Chalk R, Moreira T, MacLean EM, Marsden B, Bountra C, Burgess-Brown NA, Dafforn TR, Carpenter EP, Sauer DB

EMDB-17380: 
Structure of human SIT1 bound to L-pipecolate (focussed map / refinement)
Method: single particle / : Li HZ, Pike ACW, Chi G, Hansen JS, Lee SG, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Chalk R, Moreira T, MacLean EM, Marsden B, Bountra C, Burgess-Brown NA, Dafforn TR, Carpenter EP, Sauer DB

EMDB-17381: 
Structure of human SIT1:ACE2 complex (open PD conformation) bound to L-pipecolate
Method: single particle / : Li HZ, Pike ACW, Chi G, Hansen JS, Lee SG, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Chalk R, Moreira T, MacLean EM, Marsden B, Bountra C, Burgess-Brown NA, Dafforn TR, Carpenter EP, Sauer DB

EMDB-17382: 
Structure of human SIT1:ACE2 complex (closed PD conformation) bound to L-pipecolate
Method: single particle / : Li HZ, Pike ACW, Chi G, Hansen JS, Lee SG, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Chalk R, Moreira T, MacLean EM, Marsden B, Bountra C, Burgess-Brown NA, Dafforn TR, Carpenter EP, Sauer DB

EMDB-17197: 
Human TPC2 in Complex with Antagonist (S)-SG-094
Method: single particle / : Chi G, Pike ACW, Maclean EM, Li H, Mukhopadhyay SMM, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Duerr K

EMDB-19108: 
Human TPC2 in Complex withAntagonist (R)-SG-094
Method: single particle / : Chi G, Pike ACW, Maclean EM, Li H, Mukhopadhyay SMM, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Duerr K

EMDB-19066: 
TREK2 in OGNG/CHS detergent micelle with biparatopic inhibitory nanobody Nb6158
Method: single particle / : Smith KHM, Tucker SJ

EMDB-18659: 
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1
Method: single particle / : Chi G, Mckinley G, Marsden B, Pike ACW, Ye M, Brooke LM, Bakshi S, Pilati N, Marasco A, Gunthorpe M, Alvaro G, Large C, Lakshminaraya B, Williams E, Sauer DB

EMDB-18660: 
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5
Method: single particle / : Chi G, Mckinley G, Marsden B, Pike ACW, Ye M, Brooke LM, Bakshi S, Lakshminarayana B, Pilati N, Marasco A, Gunthorpe M, Alvaro GS, Large CH, Williams E, Sauer DB

EMDB-16110: 
Human Urea Transporter UT-A (N-Terminal Domain Model)
Method: single particle / : Chi G, Pike ACW, Maclean EM, Mukhopadhyay SMM, Bohstedt T, Scacioc A, Wang D, McKinley G, Fernandez-Cid A, Arrowsmith CH, Bountra C, Edwards A, Burgess-Brown NA, van Putte W, Duerr K

EMDB-16111: 
Map of Human Urea Transporter UT-A Collected with 0 and 30 Degree Tilts
Method: single particle / : Chi G, Pike ACW, Maclean EM, Bohstedt T, Wang D, Mckinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Edwards A, Arrowsmith C, Bountra C, Duerr KL

EMDB-16112: 
Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14
Method: single particle / : Chi G, Dietz L, Pike ACW, Maclean EM, Mukhopadhyay SMM, Bohstedt T, Wang D, Scacioc A, McKinley G, Arrowsmith CH, Edwards A, Bountra C, Fernandez-Cid A, Burgess-Brown NA, Duerr KL

EMDB-13036: 
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2
Method: single particle / : Grieben M, Pike ACW

EMDB-13037: 
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1
Method: single particle / : Grieben M, Pike ACW

EMDB-12566: 
Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Method: single particle / : Baronina A, Pike ACW

EMDB-11804: 
Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS)
Method: single particle / : Chi G, Man H, Pike ACW, Wang D, McKinley G, Mukhopadhyay SMM, MacLean EM, Chalk R, Moreau C, Snee M, Abrusci P, Arrowsmith CH, Bountra C, Edwards AM, Marsden BD, Burgess-Brown NA, Duerr KL

EMDB-11805: 
Structure of Wild-type Human Potassium Chloride Transporter KCC3 in NaCl (MSP E3D1)
Method: single particle / : Chi G, Man H, Pike ACW, Wang D, McKinley G, Mukhopadhyay SMM, MacLean EM, Chalk R, Moreau C, Snee M, Abrusci P, Arrowsmith CH, Bountra C, Edwards AM, Marsden BD, Burgess-Brown NA, Duerr KL

EMDB-13035: 
Cryo-EM structure of human TMEM45A
Method: single particle / : Grieben M, Pike ACW

EMDB-12311: 
Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS)
Method: single particle / : Chi G, Man H, Pike ACW, Wang D, McKinley G, Mukhopadhyay SMM, MacLean EM, Chalk R, Moreau C, Snee M, Abrusci P, Arrowsmith CH, Bountra C, Edwards AM, Marsden BD, Burgess-Brown NA, Duerr KL

EMDB-11674: 
Cryo-EM structure of the cytoplasmic domain of human TRPC6
Method: single particle / : Grieben M, Pike ACW

EMDB-10094: 
Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA
Method: single particle / : Baronina A, Pike ACW

EMDB-10703: 
Structure of Human Potassium Chloride Transporter KCC3 in NaCl
Method: single particle / : Chi G, Man H

EMDB-10418: 
CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2
Method: single particle / : Wang Q, Pike ACW

EMDB-10419: 
CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(3,5)P2
Method: single particle / : Wang Q, Pike ACW

EMDB-0093: 
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Method: single particle / : Shintre CA, Pike ACW

EMDB-4746: 
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Method: single particle / : Pike ACW, Bushell SR

EMDB-4747: 
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Method: single particle / : Pike ACW, Bushell SR

EMDB-4748: 
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Method: single particle / : Pike ACW, Bushell SR

EMDB-0094: 
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Method: single particle / : Shintre CA, Pike ACW
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