Author results

4FZP
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CRYSTAL STRUCTURE OF THE URANYL BINDING PROTEIN COMPLEXED WITH URANYL
Descriptor:uranyl binding protein, URANYL (VI) ION
Authors:Zhou, L., Zhang, L., He, C.
Deposit date:2012-07-06
Release date:2013-12-11
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:A protein engineered to bind uranyl selectively and with femtomolar affinity.
Nat Chem, 6, 2014
4FZO
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CRYSTAL STRUCTURE OF THE APO-FORM URANYL BINDING PROTEIN
Descriptor:uranyl binding protein
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-07-06
Release date:2013-12-11
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A protein engineered to bind uranyl selectively and with femtomolar affinity.
Nat Chem, 6, 2014
4GWG
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CRYSTAL STRUCTURE ANALYSIS OF 6-PHOSPHOGLUCONATE DEHYDROGENASE APO-FORM
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-09-03
Release date:2012-11-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3907 Å)
Cite:Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer Cell, 22, 2012
4HK2
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U7UB25.2540
Descriptor:Ubiquitin, SULFATE ION
Authors:Murray, J.M., Rouge, L.
Deposit date:2012-10-14
Release date:2012-11-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
5IT3
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SWIRM DOMAIN OF HUMAN LSD1
Descriptor:Lysine-specific histone demethylase 1A, MAGNESIUM ION
Authors:Jeffrey, P.D., Yuan, P.
Deposit date:2016-03-16
Release date:2016-05-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Tlx-interacting peptide of Lsd1 inhibits the proliferation of brain tumor stem cells
To Be Published
2QIF
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CRYSTAL STRUCTURE OF A METALLOCHAPERONE WITH A TETRANUCLEAR CU(I) CLUSTER
Descriptor:Copper chaperone copZ, COPPER (I) ION, ACETATE ION, ...
Authors:West, C., Singleton, C., Kihlken, M.A., Le Brun, N.E., Hemmings, A.M.
Deposit date:2007-07-04
Release date:2008-07-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ.
Biochemistry, 48, 2009
5V0J
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RNA DUPLEX WITH 2-MEIMPG ANALOGUE BOUND-2 BINDING SITES
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3'), 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine, MAGNESIUM ION
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-02-28
Release date:2017-03-08
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
6AKK
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CRYSTAL STRUCTURE OF THE SECOND COILED-COIL DOMAIN OF SIKE1
Descriptor:Suppressor of IKBKE 1, GLYCEROL
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
4GWK
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CRYSTAL STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE COMPLEXED WITH 3-PHOSPHOGLYCERIC ACID
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, 3-PHOSPHOGLYCERIC ACID, ...
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-09-03
Release date:2012-11-28
Method:X-RAY DIFFRACTION (1.534 Å)
Cite:Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer Cell, 22, 2012
4JNF
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ALLOSTERIC OPENING OF THE POLYPEPTIDE-BINDING SITE WHEN AN HSP70 BINDS ATP
Descriptor:Hsp70 CHAPERONE DnaK
Authors:Qi, R., Sarbeng, E.B., Liu, Q., Le, K.Q., Xu, X., Xu, H., Yang, J., Wong, J.L., Vorvis, C., Hendrickson, W.A., Zhou, L., Liu, Q.
Deposit date:2013-03-15
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.621 Å)
Cite:Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.
Nat.Struct.Mol.Biol., 20, 2013
4GPZ
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CRYSTAL STRUCTURE OF HUMAN B TYPE PHOSPHOGLYCERATE MUTASE H11 PHOSPHORYLATED FORM
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-08-22
Release date:2013-05-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Nat Commun, 4, 2013
6AKL
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CRYSTAL STRUCTURE OF STRIATIN3 IN COMPLEX WITH SIKE1 COILED-COIL DOMAIN
Descriptor:Suppressor of IKBKE 1, Striatin-3
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
4HJK
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U7UB7 DISULFIDE VARIANT
Descriptor:Ubiquitin, PHOSPHATE ION
Authors:Murray, J.M., Rouge, L.
Deposit date:2012-10-12
Release date:2012-11-21
Method:X-RAY DIFFRACTION (1.784 Å)
Cite:Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
1G55
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STRUCTURE OF HUMAN DNMT2, AN ENIGMATIC DNA METHYLTRANSFERASE HOMOLOGUE
Descriptor:DNA CYTOSINE METHYLTRANSFERASE DNMT2, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, A., Yoder, J.A., Zhang, X., Zhou, L., Bestor, T.H., Cheng, X.
Deposit date:2000-10-30
Release date:2001-01-17
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
Nucleic Acids Res., 29, 2001
5EB1
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THE YFIB-YFIR COMPLEX
Descriptor:YfiR, YfiB, SULFATE ION
Authors:Xu, M., Yang, X., Yang, X.-A., Zhou, L., Liu, T.-Z., Fan, Z., Jiang, T.
Deposit date:2015-10-17
Release date:2016-05-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system
Protein Cell, 7, 2016
4NMX
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PCSK9(DELTACRD) IN COMPLEX WITH PHAGE-DERIVED INHIBITORY PEPTIDE 2-8
Descriptor:Proprotein convertase subtilisin/kexin type 9, peptide 2-8
Authors:Eigenbrot, C., Shia, S.
Deposit date:2013-11-15
Release date:2013-12-04
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor.
J.Biol.Chem., 289, 2014
6ASY
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BIP-ATP2
Descriptor:78 kDa glucose-regulated protein, GLYCEROL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Liu, Q., Yang, J., Zong, Y., Columbus, L., Zhou, L.
Deposit date:2017-08-26
Release date:2017-12-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s.
Nat Commun, 8, 2017
4APO
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AIP TPR DOMAIN IN COMPLEX WITH HUMAN TOMM20 PEPTIDE
Descriptor:AH RECEPTOR-INTERACTING PROTEIN, MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG, DODECAETHYLENE GLYCOL, ...
Authors:Morgan, R.M.L., Roe, S.M., Pearl, L.H., Prodromou, C.
Deposit date:2012-04-04
Release date:2013-01-23
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition.
Plos One, 7, 2012
5YF4
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A KINASE COMPLEX MST4-MOB4
Descriptor:MOB-like protein phocein, Peptide from Serine/threonine-protein kinase 26, ZINC ION
Authors:Chen, M., Zhou, Z.C.
Deposit date:2017-09-20
Release date:2018-08-15
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.
J. Biol. Chem., 293, 2018
3I9Z
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CRYSTAL STRUCTURE OF A METALLOCHAPERONE WITH A TRINUCLEAR CU(I) CLUSTER
Descriptor:Copper chaperone copZ, COPPER (I) ION
Authors:Hearnshaw, S.J., Zhou, L., Le Brun, N.E., Hemmings, A.M.
Deposit date:2009-07-13
Release date:2009-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA.
Biochem.J., 424, 2009
5HSM
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, SULFATE ION
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2016-01-26
Release date:2017-02-01
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5V0H
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RNA DUPLEX WITH 2-MEIMPG ANALOGUE BOUND-ONE BINDING SITE
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3'), 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine, MAGNESIUM ION
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-02-28
Release date:2017-03-08
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
5WY2
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HUMAN SNX5 PX DOMAIN IN COMPLEX WITH CHLAMYDIA INCE C TERMINUS
Descriptor:Sorting nexin-5, IncE
Authors:Sun, Q., Yong, X., Jia, D.
Deposit date:2017-01-10
Release date:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional insights into sorting nexin 5/6 interaction with bacterial effector IncE
Signal Transduct Target Ther, 2, 2017
5Y2I
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PHOSPHOGLYCERATE MUTASE 1 (PGAM1) COMPLEXED WITH ITS INHIBITOR PGMI-004A
Descriptor:Phosphoglycerate mutase 1, 3,4-bis(oxidanyl)-9,10-bis(oxidanylidene)-~{N}-[4-(trifluoromethyl)phenyl]anthracene-2-sulfonamide, CHLORIDE ION, ...
Authors:Jiang, L., Zhou, L.
Deposit date:2017-07-26
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.917 Å)
Cite:Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor PGMI-004A
To Be Published
4JNE
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ALLOSTERIC OPENING OF THE POLYPEPTIDE-BINDING SITE WHEN AN HSP70 BINDS ATP
Descriptor:Hsp70 CHAPERONE DnaK, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Qi, R., Sarbeng, E.B., Liu, Q., Le, K.Q., Xu, X., Xu, H., Yang, J., Wong, J.L., Vorvis, C., Hendrickson, W.A., Zhou, L., Liu, Q.
Deposit date:2013-03-15
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.
Nat.Struct.Mol.Biol., 20, 2013