Author results

4M75
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CRYSTAL STRUCTURE OF LSM1-7 COMPLEX
Descriptor:U6 snRNA-associated Sm-like protein Lsm1, U6 snRNA-associated Sm-like protein Lsm2, U6 snRNA-associated Sm-like protein Lsm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-10-23
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M77
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP I212121
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.111 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M78
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP P21
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7A
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE 3' END SEQUENCE OF U6 SNRNA
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7D
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE RNA FRAGMENT CGUUU
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4FZP
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CRYSTAL STRUCTURE OF THE URANYL BINDING PROTEIN COMPLEXED WITH URANYL
Descriptor:uranyl binding protein, URANYL (VI) ION
Authors:Zhou, L., Zhang, L., He, C.
Deposit date:2012-07-06
Release date:2013-12-11
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:A protein engineered to bind uranyl selectively and with femtomolar affinity.
Nat Chem, 6, 2014
1M0E
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ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE
Descriptor:5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(Z)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ...
Authors:Zhou, L., Cheng, X., Connolly, B.A., Dickman, M.J., Hurd, P.J., Hornby, D.P.
Deposit date:2002-06-12
Release date:2002-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES
J.MOL.BIOL., 321, 2002
5EIV
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CRYSTAL STRUCTURE OF COMPLEX OF OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR (OSCAR) AND A SYNTHETIC COLLAGEN CONSENSUS PEPTIDE
Descriptor:Osteoclast-associated immunoglobulin-like receptor, GLY-PRO-HYP-GLY-PRO-HYP-GLY-PRO-HYP-GLY-PRO-ALA-GLY-PHE-HYP-GLY-PRO-HYP-GLY-PRO-HYP, PRO-GLY-PRO-PRO-GLY-PRO-PRO, ...
Authors:Zhou, L., Blaszczyk, M., Chirgadze, D., Bihan, D., Farndale, R.W.
Deposit date:2015-10-30
Release date:2015-11-25
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.414 Å)
Cite:Structural basis for collagen recognition by the immune receptor OSCAR.
Blood, 127, 2016
5Y61
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YFIB-YFIR COMPLEXED WITH GMP
Descriptor:YfiR, YfiB, GUANOSINE-5'-MONOPHOSPHATE
Authors:Zhou, L., Xu, M., Jiang, T.
Deposit date:2017-08-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural insights into the functional role of GMP in modulating the YfiBNR system
Biochem. Biophys. Res. Commun., 493, 2017
5Y62
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YFIR COMPLEXED WITH GMP
Descriptor:YfiR, GUANOSINE-5'-MONOPHOSPHATE
Authors:Zhou, L., Xu, M., Jiang, T.
Deposit date:2017-08-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the functional role of GMP in modulating the YfiBNR system
Biochem. Biophys. Res. Commun., 493, 2017
5Y64
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PHOSPHOGLYCERATE MUTASE 1 H11 PHOSPHORYLATED FORM COMPLEXED WITH KH1
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Zhou, L., Jiang, L.L.
Deposit date:2017-08-10
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Phosphoglycerate mutase 1 H11 phosphorylated form complexed with KH1
To Be Published
6AKK
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CRYSTAL STRUCTURE OF THE SECOND COILED-COIL DOMAIN OF SIKE1
Descriptor:Suppressor of IKBKE 1, GLYCEROL
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6AKL
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CRYSTAL STRUCTURE OF STRIATIN3 IN COMPLEX WITH SIKE1 COILED-COIL DOMAIN
Descriptor:Suppressor of IKBKE 1, Striatin-3
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
5GON
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STRUCTURES OF A BETA-LACTAM BRIDGED ANALOGUE IN COMPLEX WITH TUBULIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhou, L., Liu, Y., Cheng, L., Wang, Y.
Deposit date:2016-07-28
Release date:2017-03-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
J. Med. Chem., 59, 2016
4FZO
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CRYSTAL STRUCTURE OF THE APO-FORM URANYL BINDING PROTEIN
Descriptor:uranyl binding protein
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-07-06
Release date:2013-12-11
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A protein engineered to bind uranyl selectively and with femtomolar affinity.
Nat Chem, 6, 2014
4GPI
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CRYSTAL STRUCTURE OF HUMAN B TYPE PHOSPHOGLYCERATE MUTASE
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION
Authors:Zhou, L., He, C.
Deposit date:2012-08-21
Release date:2013-05-22
Method:X-RAY DIFFRACTION (2.0817 Å)
Cite:Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Nat Commun, 4, 2013
5Y2U
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X-RAY STRUCTURE OF PHOSPHOGLYCERATE MUTASE 1(PGAM1) COMPLEXED WITH A SMALL MOLECULE
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, ALIZARIN RED, ...
Authors:Jiang, L.L., Zhou, L.
Deposit date:2017-07-27
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:X-ray structure of Phosphoglycerate Mutase 1(PGAM1) complexed with a small molecule
To Be Published
4GPZ
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CRYSTAL STRUCTURE OF HUMAN B TYPE PHOSPHOGLYCERATE MUTASE H11 PHOSPHORYLATED FORM
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-08-22
Release date:2013-05-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Nat Commun, 4, 2013
4GWG
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CRYSTAL STRUCTURE ANALYSIS OF 6-PHOSPHOGLUCONATE DEHYDROGENASE APO-FORM
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-09-03
Release date:2012-11-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3907 Å)
Cite:Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer Cell, 22, 2012
4GWK
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CRYSTAL STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE COMPLEXED WITH 3-PHOSPHOGLYCERIC ACID
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, 3-PHOSPHOGLYCERIC ACID, ...
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-09-03
Release date:2012-11-28
Method:X-RAY DIFFRACTION (1.534 Å)
Cite:Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer Cell, 22, 2012
5Y2I
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PHOSPHOGLYCERATE MUTASE 1 (PGAM1) COMPLEXED WITH ITS INHIBITOR PGMI-004A
Descriptor:Phosphoglycerate mutase 1, 3,4-bis(oxidanyl)-9,10-bis(oxidanylidene)-~{N}-[4-(trifluoromethyl)phenyl]anthracene-2-sulfonamide, CHLORIDE ION, ...
Authors:Jiang, L., Zhou, L.
Deposit date:2017-07-26
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.917 Å)
Cite:Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor PGMI-004A
To Be Published
6ASY
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BIP-ATP2
Descriptor:78 kDa glucose-regulated protein, GLYCEROL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Liu, Q., Yang, J., Zong, Y., Columbus, L., Zhou, L.
Deposit date:2017-08-26
Release date:2017-12-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s.
Nat Commun, 8, 2017
3LRB
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STRUCTURE OF E. COLI ADIC
Descriptor:Arginine/agmatine antiporter
Authors:Gao, X., Lu, F., Zhou, L., Shi, Y.
Deposit date:2010-02-10
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.61 Å)
Cite:Structure and mechanism of an amino acid antiporter
Science, 324, 2009
3LRC
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STRUCTURE OF E. COLI ADIC (P1)
Descriptor:Arginine/agmatine antiporter
Authors:Gao, X., Lu, F., Zhou, L., Shi, Y.
Deposit date:2010-02-11
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.004 Å)
Cite:Structure and mechanism of an amino acid antiporter
Science, 324, 2009
1F3L
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CRYSTAL STRUCTURE OF THE CONSERVED CORE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT3
Descriptor:PROTEIN ARGININE METHYLTRANSFERASE PRMT3, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Zhang, X., Zhou, L., Cheng, X.
Deposit date:2000-06-05
Release date:2001-03-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structure of the conserved core of protein arginine methyltransferase PRMT3.
EMBO J., 19, 2000
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