Author results

4M75
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CRYSTAL STRUCTURE OF LSM1-7 COMPLEX
Descriptor:U6 snRNA-associated Sm-like protein Lsm1, U6 snRNA-associated Sm-like protein Lsm2, U6 snRNA-associated Sm-like protein Lsm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-10-23
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M77
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP I212121
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.111 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M78
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP P21
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7A
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE 3' END SEQUENCE OF U6 SNRNA
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7D
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE RNA FRAGMENT CGUUU
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4FZP
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CRYSTAL STRUCTURE OF THE URANYL BINDING PROTEIN COMPLEXED WITH URANYL
Descriptor:uranyl binding protein, URANYL (VI) ION
Authors:Zhou, L., Zhang, L., He, C.
Deposit date:2012-07-06
Release date:2013-12-11
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:A protein engineered to bind uranyl selectively and with femtomolar affinity.
Nat Chem, 6, 2014
6QUM
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THERMUS THERMOPHILUS V/A-TYPE ATPASE/SYNTHASE, ROTATIONAL STATE 1
Descriptor:V-type ATP synthase alpha chain, V-type ATP synthase beta chain, V-type ATP synthase subunit D, ...
Authors:Zhou, L., Sazanov, L.
Deposit date:2019-02-27
Release date:2019-08-28
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structure and conformational plasticity of the intactThermus thermophilusV/A-type ATPase.
Science, 365, 2019
6R0W
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THERMUS THERMOPHILUS V/A-TYPE ATPASE/SYNTHASE, ROTATIONAL STATE 2
Descriptor:V-type ATP synthase alpha chain, V-type ATP synthase beta chain, V-type ATP synthase subunit D, ...
Authors:Zhou, L., Sazanov, L.
Deposit date:2019-03-13
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and conformational plasticity of the intactThermus thermophilusV/A-type ATPase.
Science, 365, 2019
6R0Y
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THERMUS THERMOPHILUS V/A-TYPE ATPASE/SYNTHASE, ROTATIONAL STATE 3
Descriptor:V-type ATP synthase alpha chain, V-type ATP synthase beta chain, V-type ATP synthase subunit D, ...
Authors:Zhou, L., Sazanov, L.
Deposit date:2019-03-13
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure and conformational plasticity of the intactThermus thermophilusV/A-type ATPase.
Science, 365, 2019
6R0Z
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THERMUS THERMOPHILUS V/A-TYPE ATPASE/SYNTHASE, ROTATIONAL STATE 1L
Descriptor:V-type ATP synthase alpha chain, V-type ATP synthase beta chain, V-type ATP synthase subunit D, ...
Authors:Zhou, L., Sazanov, L.
Deposit date:2019-03-13
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure and conformational plasticity of the intactThermus thermophilusV/A-type ATPase.
Science, 365, 2019
6R10
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THERMUS THERMOPHILUS V/A-TYPE ATPASE/SYNTHASE, ROTATIONAL STATE 1R
Descriptor:V-type ATP synthase alpha chain, V-type ATP synthase beta chain, V-type ATP synthase subunit D, ...
Authors:Zhou, L., Sazanov, L.
Deposit date:2019-03-13
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure and conformational plasticity of the intactThermus thermophilusV/A-type ATPase.
Science, 365, 2019
1M0E
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ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE
Descriptor:5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(Z)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ...
Authors:Zhou, L., Cheng, X., Connolly, B.A., Dickman, M.J., Hurd, P.J., Hornby, D.P.
Deposit date:2002-06-12
Release date:2002-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES
J.MOL.BIOL., 321, 2002
5EIV
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CRYSTAL STRUCTURE OF COMPLEX OF OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR (OSCAR) AND A SYNTHETIC COLLAGEN CONSENSUS PEPTIDE
Descriptor:Osteoclast-associated immunoglobulin-like receptor, GLY-PRO-HYP-GLY-PRO-HYP-GLY-PRO-HYP-GLY-PRO-ALA-GLY-PHE-HYP-GLY-PRO-HYP-GLY-PRO-HYP, PRO-GLY-PRO-PRO-GLY-PRO-PRO, ...
Authors:Zhou, L., Blaszczyk, M., Chirgadze, D., Bihan, D., Farndale, R.W.
Deposit date:2015-10-30
Release date:2015-11-25
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.414 Å)
Cite:Structural basis for collagen recognition by the immune receptor OSCAR.
Blood, 127, 2016
5Y61
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YFIB-YFIR COMPLEXED WITH GMP
Descriptor:YfiR, YfiB, GUANOSINE-5'-MONOPHOSPHATE
Authors:Zhou, L., Xu, M., Jiang, T.
Deposit date:2017-08-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural insights into the functional role of GMP in modulating the YfiBNR system
Biochem. Biophys. Res. Commun., 493, 2017
5Y62
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YFIR COMPLEXED WITH GMP
Descriptor:YfiR, GUANOSINE-5'-MONOPHOSPHATE
Authors:Zhou, L., Xu, M., Jiang, T.
Deposit date:2017-08-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the functional role of GMP in modulating the YfiBNR system
Biochem. Biophys. Res. Commun., 493, 2017
5Y64
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PHOSPHOGLYCERATE MUTASE 1 H11 PHOSPHORYLATED FORM COMPLEXED WITH KH1
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Zhou, L., Jiang, L.L.
Deposit date:2017-08-10
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Phosphoglycerate mutase 1 H11 phosphorylated form complexed with KH1
To Be Published
6AKK
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CRYSTAL STRUCTURE OF THE SECOND COILED-COIL DOMAIN OF SIKE1
Descriptor:Suppressor of IKBKE 1, GLYCEROL
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6AKL
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CRYSTAL STRUCTURE OF STRIATIN3 IN COMPLEX WITH SIKE1 COILED-COIL DOMAIN
Descriptor:Suppressor of IKBKE 1, Striatin-3
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
5GON
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STRUCTURES OF A BETA-LACTAM BRIDGED ANALOGUE IN COMPLEX WITH TUBULIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhou, L., Liu, Y., Cheng, L., Wang, Y.
Deposit date:2016-07-28
Release date:2017-03-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
J. Med. Chem., 59, 2016
4FZO
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CRYSTAL STRUCTURE OF THE APO-FORM URANYL BINDING PROTEIN
Descriptor:uranyl binding protein
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-07-06
Release date:2013-12-11
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A protein engineered to bind uranyl selectively and with femtomolar affinity.
Nat Chem, 6, 2014
4GPI
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CRYSTAL STRUCTURE OF HUMAN B TYPE PHOSPHOGLYCERATE MUTASE
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION
Authors:Zhou, L., He, C.
Deposit date:2012-08-21
Release date:2013-05-22
Method:X-RAY DIFFRACTION (2.0817 Å)
Cite:Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Nat Commun, 4, 2013
5Y2U
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X-RAY STRUCTURE OF PHOSPHOGLYCERATE MUTASE 1(PGAM1) COMPLEXED WITH A SMALL MOLECULE
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, ALIZARIN RED, ...
Authors:Jiang, L.L., Zhou, L.
Deposit date:2017-07-27
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:X-ray structure of Phosphoglycerate Mutase 1(PGAM1) complexed with a small molecule
To Be Published
6KXW
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CRYSTAL STRUCTURE OF HUMAN AQUAPORIN AQP7 IN BOUND TO GLYCEROL
Descriptor:Aquaporin-7, GLYCEROL
Authors:Zhang, L., Yao, D., Zhou, F., Zhang, Q., Zhou, L., Cao, Y.
Deposit date:2019-09-13
Release date:2019-11-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The Structural Basis for Glycerol Permeation by human AQP
To Be Published
4GPZ
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CRYSTAL STRUCTURE OF HUMAN B TYPE PHOSPHOGLYCERATE MUTASE H11 PHOSPHORYLATED FORM
Descriptor:Phosphoglycerate mutase 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-08-22
Release date:2013-05-22
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Nat Commun, 4, 2013
4GWG
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CRYSTAL STRUCTURE ANALYSIS OF 6-PHOSPHOGLUCONATE DEHYDROGENASE APO-FORM
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Zhou, L., Zhang, L.
Deposit date:2012-09-03
Release date:2012-11-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3907 Å)
Cite:Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer Cell, 22, 2012