Author results

2ICJ
  • Download 2icj
  • View 2icj
Molmil generated image of 2icj
THE CRYSTAL STRUCTURE OF HUMAN ISOPENTENYL DIPHOPHATE ISOMERASE
Descriptor:Isopentenyl-diphosphate delta isomerase, MAGNESIUM ION, SULFATE ION
Authors:Zheng, W., Bartlam, M., Rao, Z.
Deposit date:2006-09-12
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis
J.Mol.Biol., 366, 2007
2ICK
  • Download 2ick
  • View 2ick
Molmil generated image of 2ick
HUMAN ISOPENTENYL DIPHOPHATE ISOMERASE COMPLEXED WITH SUBSTRATE ANALOG
Descriptor:Isopentenyl-diphosphate delta isomerase, MANGANESE (II) ION, DIMETHYLALLYL DIPHOSPHATE
Authors:Zheng, W., Bartlam, M., Rao, Z.
Deposit date:2006-09-12
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis
J.Mol.Biol., 366, 2007
4EWC
  • Download 4ewc
  • View 4ewc
Molmil generated image of 4ewc
CRYSTAL STRUCTURE OF THE INFECTIOUS SALMON ANEMIA VIRUS NUCLEOPROTEIN
Descriptor:Putative nucleoprotein
Authors:Zheng, W., Tao, Y.J.
Deposit date:2012-04-26
Release date:2013-05-08
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure and RNA-binding of an orthomyxovirus nucleoprotein.
Plos Pathog., 9, 2013
5W5F
  • Download 5w5f
  • View 5w5f
Molmil generated image of 5w5f
CRYO-EM STRUCTURE OF THE T4 TAIL TUBE
Descriptor:Tail tube protein gp19
Authors:Zheng, W., Wang, F., Taylor, N.M., Guerrero-Ferreira, R.C., Leiman, P.G., Egelman, E.H.
Deposit date:2017-06-15
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.
Structure, 25, 2017
6D1W
  • Download 6d1w
  • View 6d1w
Molmil generated image of 6d1w
HUMAN PKD2 F604P MUTANT
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Zheng, W., Yang, X., Bulkley, D., Chen, X.Z., Cao, E.
Deposit date:2018-04-12
Release date:2018-06-27
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Nat Commun, 9, 2018
4FMU
  • Download 4fmu
  • View 4fmu
Molmil generated image of 4fmu
CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN SET DOMAIN-CONTAINING PROTEIN 2 COMPOUND: PR-SNF
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, ...
Authors:Dong, A., Zeng, H., Ibanez, G., Zheng, W., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2012-06-18
Release date:2012-09-05
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.
J.Am.Chem.Soc., 134, 2012
1A6R
  • Download 1a6r
  • View 1a6r
Molmil generated image of 1a6r
GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A
Descriptor:GAL6, SULFATE ION
Authors:Joshua-Tor, L., Zheng, W., Johnston, S.A.
Deposit date:1998-02-27
Release date:1998-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.
Cell(Cambridge,Mass.), 93, 1998
3GCB
  • Download 3gcb
  • View 3gcb
Molmil generated image of 3gcb
GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454
Descriptor:GAL6, SULFATE ION, GLYCEROL
Authors:Joshua-Tor, L., Zheng, W., Johnston, S.A.
Deposit date:1998-02-27
Release date:1998-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.
Cell(Cambridge,Mass.), 93, 1998
5W5E
  • Download 5w5e
  • View 5w5e
Molmil generated image of 5w5e
RE-REFINEMENT OF THE PYOCIN TUBE STRUCTURE
Descriptor:FIIR2 protein
Authors:Wang, F., Zheng, W., Taylor, N.M., Guerrero-Ferreira, R.C., Leiman, P.G., Egelman, E.H.
Deposit date:2017-06-15
Release date:2017-08-16
Last modified:2017-09-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.
Structure, 25, 2017
6C53
  • Download 6c53
  • View 6c53
Molmil generated image of 6c53
CRYO-EM STRUCTURE OF THE TYPE 1 PILUS ROD
Descriptor:Type-1 fimbrial protein, A chain
Authors:Zheng, W., Wang, F., Luna-Rico, A., Francetic, O., Hultgren, S.J., Egelman, E.H.
Deposit date:2018-01-13
Release date:2018-01-31
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.
Elife, 7, 2018
6MKS
  • Download 6mks
  • View 6mks
Molmil generated image of 6mks
CRYO-EM STRUCTURE OF NLRC4-CARD FILAMENT
Descriptor:Chimera protein of NLR family CARD domain-containing protein 4 and EGFP
Authors:Zheng, W., Matyszewski, M., Sohn, J., Egelman, E.H.
Deposit date:2018-09-26
Release date:2018-11-07
Last modified:2019-01-09
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.
J. Biol. Chem., 293, 2018
5WCO
  • Download 5wco
  • View 5wco
Molmil generated image of 5wco
MATRIX PROTEIN (M1) OF INFECTIOUS SALMON ANAEMIA VIRUS
Descriptor:NS2
Authors:Zhang, W., Zheng, W., Toh, Y., Betancourt, M.A., Tu, J., Fan, Y., Vakharia, V., Liu, J., McNew, J.A., Jin, M., Tao, Y.J.
Deposit date:2017-07-01
Release date:2017-08-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6D2L
  • Download 6d2l
  • View 6d2l
Molmil generated image of 6d2l
CRYSTAL STRUCTURE OF HUMAN CARM1 WITH (S)-SKI-72
Descriptor:Histone-arginine methyltransferase CARM1, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide, SULFATE ION, ...
Authors:DONG, A., ZENG, H., WALKER, J.R., Hutchinson, A., Seitova, A., LUO, M., CAI, X.C., KE, W., WANG, J., SHI, C., ZHENG, W., LEE, J.P., IBANEZ, G., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-04-13
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human CARM1 with (S)-SKI-72
to be published
6DVR
  • Download 6dvr
  • View 6dvr
Molmil generated image of 6dvr
CRYSTAL STRUCTURE OF HUMAN CARM1 WITH (R)-SKI-72
Descriptor:Histone-arginine methyltransferase CARM1, (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
Authors:Dong, A., Zeng, H., Hutchinson, A., Seitova, A., Luo, M., Cai, X.C., Ke, W., Wang, J., Shi, C., Zheng, W., Lee, J.P., Ibanez, G., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2018-06-25
Release date:2018-07-25
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of human CARM1 with (R)-SKI-72
to be published
1CB5
  • Download 1cb5
  • View 1cb5
Molmil generated image of 1cb5
HUMAN BLEOMYCIN HYDROLASE.
Descriptor:BLEOMYCIN HYDROLASE
Authors:O'Farrell, P.A., Gonzalez, F., Zheng, W., Johnston, S.A., Joshua-Tor, L.
Deposit date:1999-03-01
Release date:2000-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.
Structure Fold.Des., 7, 1999
2CB5
  • Download 2cb5
  • View 2cb5
Molmil generated image of 2cb5
HUMAN BLEOMYCIN HYDROLASE, C73S/DELE455 MUTANT
Descriptor:PROTEIN (BLEOMYCIN HYDROLASE)
Authors:O'Farrell, P.A., Gonzalez, F., Zheng, W., Johnston, S.A., Joshua-Tor, L.
Deposit date:1999-03-02
Release date:2000-03-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.
Structure Fold.Des., 7, 1999
3D4B
  • Download 3d4b
  • View 3d4b
Molmil generated image of 3d4b
CRYSTAL STRUCTURE OF SIR2TM IN COMPLEX WITH ACETYL P53 PEPTIDE AND DADME-NAD+
Descriptor:NAD-dependent deacetylase, Acetyl P53 peptide, ZINC ION, ...
Authors:Hawse, W.F., Hoff, K.G., Fatkins, D., Daines, A., Zubkova, O.V., Schramm, V.L., Zheng, W., Wolberger, C.
Deposit date:2008-05-14
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into intermediate steps in the Sir2 deacetylation reaction.
Structure, 16, 2008
3D81
  • Download 3d81
  • View 3d81
Molmil generated image of 3d81
SIR2-S-ALKYLAMIDATE COMPLEX CRYSTAL STRUCTURE
Descriptor:NAD-dependent deacetylase, S-alkylamidate intermediate, ZINC ION
Authors:Hawse, W.F., Hoff, K.G., Fatkins, D., Daines, A., Zubkova, O.V., Schramm, V.L., Zheng, W., Wolberger, C.
Deposit date:2008-05-22
Release date:2008-09-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into intermediate steps in the Sir2 deacetylation reaction.
Structure, 16, 2008
3L1N
  • Download 3l1n
  • View 3l1n
Molmil generated image of 3l1n
CRYSTAL STRUCTURE OF MP1P LIGAND BINDING DOMAIN 2 COMPLEXD WITH PALMITIC ACID
Descriptor:Cell wall antigen, PALMITIC ACID
Authors:Liao, S., Tung, E.T., Zheng, W., Chong, K., Xu, Y., Bartlam, M., Rao, Z., Yuen, K.Y.
Deposit date:2009-12-14
Release date:2010-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the Mp1p ligand binding domain 2 reveals its function as a fatty acid-binding protein.
J.Biol.Chem., 285, 2010
3RBW
  • Download 3rbw
  • View 3rbw
Molmil generated image of 3rbw
CRYSTAL STRUCTURE OF SPIRE KIND DOMAIN
Descriptor:Protein spire homolog 1
Authors:Vizcarra, C.L., Kreutz, B., Rodal, A.A., Toms, A.V., Lu, J., Zheng, W., Quinlan, M.E., Eck, M.J.
Deposit date:2011-03-30
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins
Proc.Natl.Acad.Sci.USA, 2011
4DQM
  • Download 4dqm
  • View 4dqm
Molmil generated image of 4dqm
REVEALING A MARINE NATURAL PRODUCT AS A NOVEL AGONIST FOR RETINOIC ACID RECEPTORS WITH A UNIQUE BINDING MODE AND ANTITUMOR ACTIVITY
Descriptor:Retinoic acid receptor alpha, Nuclear receptor coactivator 1, (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one
Authors:Wang, S., Wang, Z., Lin, S., Zheng, W., Wang, R., Jin, S., Chen, J., Jin, L., Li, Y.
Deposit date:2012-02-16
Release date:2012-10-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.
Biochem.J., 446, 2012
4IKP
  • Download 4ikp
  • View 4ikp
Molmil generated image of 4ikp
CRYSTAL STRUCTURE OF COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1 WITH METHYLENESINEFUNGIN
Descriptor:Histone-arginine methyltransferase CARM1, (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, ...
Authors:Dong, A., Dombrovski, L., He, H., Ibanez, G., Wernimont, A., Zheng, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2012-12-27
Release date:2013-02-13
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin
TO BE PUBLISHED
4WYB
  • Download 4wyb
  • View 4wyb
Molmil generated image of 4wyb
STRUCTURE OF THE BUD6 FLANK DOMAIN IN COMPLEX WITH ACTIN
Descriptor:Actin, alpha skeletal muscle, Bud site selection protein 6, ...
Authors:Eck, M.J., Park, E., Zheng, W.
Deposit date:2014-11-17
Release date:2015-08-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.493 Å)
Cite:Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Structure, 23, 2015
5O2Y
  • Download 5o2y
  • View 5o2y
Molmil generated image of 5o2y
NMR STRUCTURE OF THE CALCIUM BOUND FORM OF PULG, MAJOR PSEUDOPILIN FROM KLEBSIELLA OXYTOCA T2SS
Descriptor:General secretion pathway protein G, CALCIUM ION
Authors:Lopez-Castilla, A., Bardiaux, B., Vitorge, B., Thomassin, J.-L., Zheng, W., Yu, X., Egelman, E.H., Nilges, M., Francetic, O., Izadi-Pruneyre, N.
Deposit date:2017-05-23
Release date:2017-10-18
Last modified:2017-12-06
Method:SOLUTION NMR
Cite:Structure of the calcium-dependent type 2 secretion pseudopilus.
Nat Microbiol, 2, 2017
5WDA
  • Download 5wda
  • View 5wda
Molmil generated image of 5wda
STRUCTURE OF THE PULG PSEUDOPILUS
Descriptor:General secretion pathway protein G, CALCIUM ION
Authors:Lopez-Castilla, A., Thomassin, J.L., Bardiaux, B., Zheng, W., Nivaskumar, M., Yu, X., Nilges, M., Egelman, E.H., Izadi-Pruneyre, N., Francetic, O.
Deposit date:2017-07-04
Release date:2017-10-25
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structure of the calcium-dependent type 2 secretion pseudopilus.
Nat Microbiol, 2, 2017
<12>