Author results

1A2T
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STAPHYLOCOCCAL NUCLEASE, B-MERCAPTOETHANOL DISULFIDE TO V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1998-01-11
Release date:1998-04-29
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.
Protein Sci., 5, 1996
1A2U
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STAPHYLOCOCCAL NUCLEASE, V23C VARIANT, COMPLEX WITH 1-N-BUTANE THIOL AND 3',5'-THYMIDINE DIPHOSPHATE
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1998-01-11
Release date:1998-04-29
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.
Protein Sci., 5, 1996
1A3T
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STAPHYLOCOCCAL NUCLEASE, V23C VARIANT, COMPLEX WITH 2-FLUOROETHANE THIOL AND 3',5'-THYMIDINE DIPHOSPHATE
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1998-01-24
Release date:1998-04-29
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of straight chain and cyclic unnatural amino acids embedded in the core of staphylococcal nuclease.
Protein Sci., 6, 1997
1A3U
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STAPHYLOCOCCAL NUCLEASE, CYCLOHEXANE THIOL DISULFIDE TO V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1998-01-24
Release date:1998-04-29
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Comparison of straight chain and cyclic unnatural amino acids embedded in the core of staphylococcal nuclease.
Protein Sci., 6, 1997
1A3V
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STAPHYLOCOCCAL NUCLEASE, CYCLOPENTANE THIOL DISULFIDE TO V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1998-01-24
Release date:1998-04-29
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparison of straight chain and cyclic unnatural amino acids embedded in the core of staphylococcal nuclease.
Protein Sci., 6, 1997
1AEX
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STAPHYLOCOCCAL NUCLEASE, METHANE THIOL DISULFIDE TO V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1997-03-01
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.
Protein Sci., 5, 1996
2NUC
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STAPHLOCOCCAL NUCLEASE, ETHANE THIOL DISULFIDE TO V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1997-12-06
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.
Protein Sci., 5, 1996
3NUC
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STAPHLOCOCCAL NUCLEASE, 1-N-PROPANE THIOL DISULFIDE TO V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1997-12-06
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.
Protein Sci., 5, 1996
5NUC
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STAPHYLOCOCCAL NUCLEASE, 1-N-PENTANE THIOL DISULFIDE TO V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1998-01-11
Release date:1998-04-29
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.
Protein Sci., 5, 1996
1NUC
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STAPHYLOCOCCAL NUCLEASE, V23C VARIANT
Descriptor:STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Wynn, R., Harkins, P.C., Richards, F.M., Fox, R.O.
Deposit date:1997-02-15
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.
Protein Sci., 5, 1996
2CM2
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STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (P212121)
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Ala, P.J., Gonneville, L., Hillman, M.C., Becker-Pasha, M., Wei, M., Reid, B.G., Klabe, R., Yue, E.W., Wayland, B., Douty, B., Combs, A.P., Polam, P., Wasserman, Z., Bower, M., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CM3
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STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (C2)
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, CALCIUM ION
Authors:Ala, P.J., Gonneville, L., Hillman, M.C., Becker-Pasha, M., Wei, M., Reid, B.G., Klabe, R., Yue, E.W., Wayland, B., Douty, B., Combs, A.P., Polam, P., Wasserman, Z., Bower, M., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CM7
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STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, ISOTHIAZOLIDINONE ANALOG
Authors:Ala, P.J., Gonneville, L., Hillman, M.C., Becker-Pasha, M., Wei, M., Reid, B.G., Klabe, R., Yue, E.W., Wayland, B., Douty, B., Combs, A.P., Polam, P., Wasserman, Z., Bower, M., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CM8
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STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, MAGNESIUM ION
Authors:Ala, P.J., Gonneville, L., Hillman, M.C., Becker-Pasha, M., Wei, M., Reid, B.G., Klabe, R., Yue, E.W., Wayland, B., Douty, B., Combs, A.P., Polam, P., Wasserman, Z., Bower, M., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CMA
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STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-BENZOYL-L-PHENYLALANYL-4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]-L-PHENYLALANINAMIDE
Authors:Ala, P.J., Gonneville, L., Hillman, M.C., Becker-Pasha, M., Wei, M., Reid, B.G., Klabe, R., Yue, E.W., Wayland, B., Douty, B., Combs, A.P., Polam, P., Wasserman, Z., Bower, M., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CMB
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STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE, B-OCTYLGLUCOSIDE
Authors:Ala, P.J., Gonneville, L., Hillman, M.C., Becker-Pasha, M., Wei, M., Reid, B.G., Klabe, R., Yue, E.W., Wayland, B., Douty, B., Combs, A.P., Polam, P., Wasserman, Z., Bower, M., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CMC
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STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE, SULFATE ION, ...
Authors:Ala, P.J., Gonneville, L., Hillman, M.C., Becker-Pasha, M., Wei, M., Reid, B.G., Klabe, R., Yue, E.W., Wayland, B., Douty, B., Combs, A.P., Polam, P., Wasserman, Z., Bower, M., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-04
Release date:2006-08-17
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2VEU
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-[(1S)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}-1-(4-phenyl-1H-imidazol-2-yl)ethyl]-3-(trifluoromethyl)benzenesulfonamide
Authors:Douty, B., Wayland, B., Ala, P.J., Bower, M.J., Pruitt, J., Bostrom, L., Wei, M., Klabe, R., Gonneville, L., Wynn, R., Burn, T.C., Liu, P.C.C., Combs, A.P., Yue, E.W.
Deposit date:2007-10-27
Release date:2007-11-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Bioorg.Med.Chem.Lett., 18, 2008
2VEV
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CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-[(1S)-1-(4-benzyl-1H-imidazol-2-yl)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}ethyl]-3-(trifluoromethyl)benzenesulfonamide, MAGNESIUM ION
Authors:Douty, B., Wayland, B., Ala, P.J., Bower, M.J., Pruitt, J., Bostrom, L., Wei, M., Klabe, R., Gonneville, L., Wynn, R., Burn, T.C., Liu, P.C.C., Combs, A.P., Yue, E.W.
Deposit date:2007-10-27
Release date:2007-11-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Bioorg.Med.Chem.Lett., 18, 2008
2VEW
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CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, 3-fluoro-N-[(1S)-1-[4-[(2-fluorophenyl)methyl]imidazol-2-yl]-2-[4-[(5S)-1,1,3-trioxo-1,2-thiazolidin-5-yl]phenyl]ethyl]benzenesulfonamide, MAGNESIUM ION
Authors:Douty, B., Wayland, B., Ala, P.J., Bower, M.J., Pruitt, J., Bostrom, L., Wei, M., Klabe, R., Gonneville, L., Wynn, R., Burn, T.C., Liu, P.C.C., Combs, A.P., Yue, E.W.
Deposit date:2007-10-27
Release date:2007-11-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Bioorg.Med.Chem.Lett., 18, 2008
2VEX
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CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-{(1S)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}-1-[(4R)-4-(2-phenylethyl)-4,5-dihydro-1H-imidazol-2-yl]ethyl}-3-fluorobenzenesulfonamide, MAGNESIUM ION
Authors:Douty, B., Wayland, B., Ala, P.J., Bower, M.J., Pruitt, J., Bostrom, L., Wei, M., Klabe, R., Gonneville, L., Wynn, R., Burn, T.C., Liu, P.C.C., Combs, A.P., Yue, E.W.
Deposit date:2007-10-27
Release date:2007-11-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Bioorg.Med.Chem.Lett., 18, 2008
2VEY
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CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-{(1S)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}-1-[4-(3-phenylpropyl)-1H-imidazol-2-yl]ethyl}-3-fluorobenzenesulfonamide
Authors:Douty, B., Wayland, B., Ala, P.J., Bower, M.J., Pruitt, J., Bostrom, L., Wei, M., Klabe, R., Gonneville, L., Wynn, R., Burn, T.C., Liu, P.C.C., Combs, A.P., Yue, E.W.
Deposit date:2007-10-27
Release date:2007-11-06
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Bioorg.Med.Chem.Lett., 18, 2008
2CNE
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STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE- CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-({4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}ACETYL)-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE, SULFATE ION, ...
Authors:Ala, P.J., Gonneville, L., Hillman, M., Becker-Pasha, M., Yue, E.W., Douty, B., Wayland, B., Polam, P., Crawley, M.L., McLaughlin, E., Sparks, R.B., Glass, B., Takvorian, A., Combs, A.P., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-21
Release date:2006-09-27
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
J.Biol.Chem., 281, 2006
2CNF
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STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE- CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, (5S)-5-{4-[(2S)-2-(1H-BENZIMIDAZOL-2-YL)-2-(1,3-BENZOTHIAZOL-2-YLAMINO)ETHYL]PHENYL}ISOTHIAZOLIDIN-3-ONE 1,1-DIOXIDE, MAGNESIUM ION
Authors:Ala, P.J., Gonneville, L., Hillman, M., Becker-Pasha, M., Yue, E.W., Douty, B., Wayland, B., Polam, P., Crawley, M.L., McLaughlin, E., Sparks, R.B., Glass, B., Takvorian, A., Combs, A.P., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-21
Release date:2006-09-27
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
J.Biol.Chem., 281, 2006
2CNG
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STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE- CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1, N-{(1S)-2-{4-[(5R)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-[5-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOL-2-YL]ETHYL}-2,2,2-TRIFLUOROACETAMIDE, MAGNESIUM ION, ...
Authors:Ala, P.J., Gonneville, L., Hillman, M., Becker-Pasha, M., Yue, E.W., Douty, B., Wayland, B., Polam, P., Crawley, M.L., McLaughlin, E., Sparks, R.B., Glass, B., Takvorian, A., Combs, A.P., Burn, T.C., Hollis, G.F., Wynn, R.
Deposit date:2006-05-21
Release date:2006-09-27
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
J.Biol.Chem., 281, 2006
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