Author results

4L3I
  • Download 4l3i
  • View 4l3i
Molmil generated image of 4l3i
STRUCTURE OF THE MICROTUBULE ASSOCIATED PROTEIN PRC1 (PROTEIN REGULATOR OF CYTOKINESIS 1)
Descriptor:Protein regulator of cytokinesis 1
Authors:Subramanian, R., Ti, S., Tan, L., Darst, S.A., Kapoor, T.M.
Deposit date:2013-06-06
Release date:2013-07-17
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (3.6005 Å)
Cite:Marking and Measuring Single Microtubules by PRC1 and Kinesin-4.
Cell(Cambridge,Mass.), 154, 2013
4L6Y
  • Download 4l6y
  • View 4l6y
Molmil generated image of 4l6y
STRUCTURE OF THE MICROTUBULE ASSOCIATED PROTEIN PRC1 (PROTEIN REGULATOR OF CYTOKINESIS 1)
Descriptor:Protein regulator of cytokinesis 1
Authors:Subramanian, R., Ti, S., Tan, L., Darst, S.A., Kapoor, T.M.
Deposit date:2013-06-13
Release date:2013-07-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.3015 Å)
Cite:Marking and Measuring Single Microtubules by PRC1 and Kinesin-4.
Cell(Cambridge,Mass.), 154, 2013
3NRX
  • Download 3nrx
  • View 3nrx
Molmil generated image of 3nrx
INSIGHTS INTO ANTI-PARALLEL MICROTUBULE CROSSLINKING BY PRC1, A CONSERVED NON-MOTOR MICROTUBULE BINDING PROTEIN
Descriptor:Protein regulator of cytokinesis 1
Authors:Kapoor, T.M., Subramanian, R., Wilson-Kubalek, E.M., Arthur, C.P., Bick, M.J., Campbell, E.A., Darst, S.A., Milligan, R.A.
Deposit date:2010-06-30
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
3NRY
  • Download 3nry
  • View 3nry
Molmil generated image of 3nry
INSIGHTS INTO ANTI-PARALLEL MICROTUBULE CROSSLINKING BY PRC1, A CONSERVED MICROTUBULE BINDING PROTEIN
Descriptor:Protein regulator of cytokinesis 1
Authors:Kapoor, T.M., Subramanian, R., Wilson-Kubalek, E.M., Arthur, C.P., Bick, M.J., Campbell, E.A., Darst, S.A., Milligan, R.A.
Deposit date:2010-07-01
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
5YYB
  • Download 5yyb
  • View 5yyb
Molmil generated image of 5yyb
CRYSTAL STRUCTURE OF SIALIC ACID BINDING PROTEIN FROM HAEMOPHILUS DUCREYI WITH NEU5GC
Descriptor:Putative ABC transporter periplasmic binding protein, N-Glycolylneuraminic acid
Authors:Subramanian, R., Setty, T.G.
Deposit date:2017-12-08
Release date:2018-10-24
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.484 Å)
Cite:Molecular characterization of the interaction of sialic acid with the periplasmic binding protein fromHaemophilus ducreyi.
J. Biol. Chem., 293, 2018
5Z99
  • Download 5z99
  • View 5z99
Molmil generated image of 5z99
CRYSTAL STRUCTURE OF SIALIC ACID BINDING PROTEIN FROM HAEMOPHILUS DUCREYI WITH NEU5AC
Descriptor:Putative ABC transporter periplasmic binding protein, 5-N-ACETYL-BETA-D-NEURAMINIC ACID
Authors:Subramanian, R., Setty, T.G.
Deposit date:2018-02-02
Release date:2018-10-24
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.494 Å)
Cite:Molecular characterization of the interaction of sialic acid with the periplasmic binding protein fromHaemophilus ducreyi.
J. Biol. Chem., 293, 2018
5ZA4
  • Download 5za4
  • View 5za4
Molmil generated image of 5za4
CRYSTAL STRUCTURE OF SIALIC ACID BINDING PROTEIN FROM HAEMOPHILUS DUCREYI
Descriptor:Putative ABC transporter periplasmic binding protein
Authors:Setty, T.G., Subramanian, R.
Deposit date:2018-02-06
Release date:2018-10-24
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.193 Å)
Cite:Molecular characterization of the interaction of sialic acid with the periplasmic binding protein fromHaemophilus ducreyi.
J. Biol. Chem., 293, 2018
5ZSX
  • Download 5zsx
  • View 5zsx
Molmil generated image of 5zsx
CATECHOL 2,3-DIOXYGENASE WITH 3-FLUOROCATECHOL FROM DIAPHOROBACTER SP DS2
Descriptor:Catechol 2,3-dioxygenase, extradiol protein, CALCIUM ION, ...
Authors:Mishra, K., Arya, C.K., Subramanian, R., Ramanathan, G.
Deposit date:2018-04-30
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Catechol 2,3-dioxygenase with 3-fluorocatechol from Diaphorobacter sp DS2.
To Be Published
5ZSZ
  • Download 5zsz
  • View 5zsz
Molmil generated image of 5zsz
CATECHOL 2,3-DIOXYGENASE (C23O64) FROM DIAPHOROBACTER SP DS2
Descriptor:Catechol 2,3-dioxygenase, Extradiol ring cleavage protein, CALCIUM ION, ...
Authors:Mishra, K., Arya, C.K., Subramanian, R., Ramanathan, G.
Deposit date:2018-04-30
Release date:2019-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catechol 2,3-dioxygenase (C23O64) from Diaphorobacter sp DS2
To Be Published
6MLQ
  • Download 6mlq
  • View 6mlq
Molmil generated image of 6mlq
CRYO-EM STRUCTURE OF MICROTUBULE-BOUND KIF7 IN THE ADP STATE
Descriptor:Tubulin alpha-1A chain, Tubulin beta chain, Kinesin-like protein KIF7, ...
Authors:Mani, N., Jiang, S., Wilson-Kubalek, E.M., Ku, P., Milligan, R.A., Subramanian, R.
Deposit date:2018-09-27
Release date:2019-05-01
Last modified:2019-06-12
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7.
Dev.Cell, 49, 2019
6MLR
  • Download 6mlr
  • View 6mlr
Molmil generated image of 6mlr
CRYO-EM STRUCTURE OF MICROTUBULE-BOUND KIF7 IN THE AMPPNP STATE
Descriptor:Tubulin alpha-1A chain, Tubulin beta chain, Kinesin-like protein KIF7, ...
Authors:Mani, N., Jiang, S., Wilson-Kubalek, E.M., Ku, P., Milligan, R.A., Subramanian, R.
Deposit date:2018-09-27
Release date:2019-05-01
Last modified:2019-06-12
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7.
Dev.Cell, 49, 2019
6B8F
  • Download 6b8f
  • View 6b8f
Molmil generated image of 6b8f
CONTRACTED HUMAN HEAVY-CHAIN FERRITIN CRYSTAL-HYDROGEL HYBRID
Descriptor:Ferritin heavy chain, FE (III) ION, CALCIUM ION
Authors:Zhang, L., Bailey, J.B., Subramanian, R., Tezcan, F.A.
Deposit date:2017-10-07
Release date:2018-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks.
Nature, 557, 2018
6B8G
  • Download 6b8g
  • View 6b8g
Molmil generated image of 6b8g
TWICE-CONTRACTED HUMAN HEAVY-CHAIN FERRITIN CRYSTAL-HYDROGEL HYBRID
Descriptor:Ferritin heavy chain, FE (III) ION, CALCIUM ION
Authors:Zhang, L., Bailey, J.B., Subramanian, R., Tezcan, F.A.
Deposit date:2017-10-07
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks.
Nature, 557, 2018
3QJZ
  • Download 3qjz
  • View 3qjz
Molmil generated image of 3qjz
CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH BENZOTHIAZOLE 1
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-{6-[2-(methylsulfanyl)pyrimidin-4-yl]-1,3-benzothiazol-2-yl}acetamide, SULFATE ION
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2011-01-31
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
3QK0
  • Download 3qk0
  • View 3qk0
Molmil generated image of 3qk0
CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH BENZOTHIAZOLE 82
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2011-01-31
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
3S2A
  • Download 3s2a
  • View 3s2a
Molmil generated image of 3s2a
CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH A QUINOLINE INHIBITOR
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-{2-chloro-5-[4-(morpholin-4-yl)quinolin-6-yl]pyridin-3-yl}-4-fluorobenzenesulfonamide
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2011-05-16
Release date:2011-06-08
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure-Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives.
J.Med.Chem., 54, 2011
4DK5
  • Download 4dk5
  • View 4dk5
Molmil generated image of 4dk5
CRYSTAL STRUCTURE OF HUMAN PI3K-GAMMA IN COMPLEX WITH A PYRIDYL-TRIAZINE INHIBITOR
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-(2-[(6-methoxypyridin-3-yl)amino]-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2012-02-03
Release date:2012-05-16
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J.Med.Chem., 55, 2012
4F1S
  • Download 4f1s
  • View 4f1s
Molmil generated image of 4f1s
CRYSTAL STRUCTURE OF HUMAN PI3K-GAMMA IN COMPLEX WITH A PYRIDYL-TRIAZINE-SULFONAMIDE INHIBITOR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-(5-{[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]amino}-2-chloropyridin-3-yl)methanesulfonamide
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2012-05-07
Release date:2012-08-08
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg.Med.Chem.Lett., 22, 2012
4FLH
  • Download 4flh
  • View 4flh
Molmil generated image of 4flh
CRYSTAL STRUCTURE OF HUMAN PI3K-GAMMA IN COMPLEX WITH AMG511
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-(2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-{(1R)-1-[4-(methylsulfonyl)piperazin-1-yl]ethyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2012-06-14
Release date:2012-08-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511.
J.Med.Chem., 55, 2012
5F6Z
  • Download 5f6z
  • View 5f6z
Molmil generated image of 5f6z
SANDERCYANIN FLUORESCENT PROTEIN PURIFIED FROM SANDER VITREUS
Descriptor:Sandercyanin Fluorescent Protein, BILIVERDINE IX ALPHA, N-ACETYL-D-GLUCOSAMINE
Authors:Ghosh, S., Yu, C.L., Ferraro, D., Sudha, S., Pal, S., Schaefer, W., Gibson, D.T., Subramanian, R.
Deposit date:2015-12-07
Release date:2016-09-28
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.248 Å)
Cite:Blue protein with red fluorescence
Proc.Natl.Acad.Sci.USA, 113, 2016
5ZJB
  • Download 5zjb
  • View 5zjb
Molmil generated image of 5zjb
STRUCTURE OF N-ACETYLMANNOSAMINE-6-PHOSPHATE-2-EPIMERASE FROM VIBRIO CHOLERAE
Descriptor:Putative N-acetylmannosamine-6-phosphate 2-epimerase, MALONATE ION, DI(HYDROXYETHYL)ETHER
Authors:Manjunath, L., Guntupalli, S.
Deposit date:2018-03-19
Release date:2018-09-19
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae
Acta Crystallogr F Struct Biol Commun, 74, 2018
5ZJM
  • Download 5zjm
  • View 5zjm
Molmil generated image of 5zjm
CRYSTAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM FUSOBACTERIUM NUCLEATUM
Descriptor:N-acetylneuraminate lyase, 1,2-ETHANEDIOL
Authors:Kumar, J.P., Rao, H., Nayak, V., Subramanian, R.
Deposit date:2018-03-21
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum
Acta Crystallogr F Struct Biol Commun, 74, 2018
5ZJN
  • Download 5zjn
  • View 5zjn
Molmil generated image of 5zjn
STRUCTURE OF N-ACETYLMANNOSAMINE-6-PHOSPHATE-2-EPIMERASE FROM VIBRIO CHOLERAE WITH N-ACETYLMANNOSAMINE-6-PHOSPHATE
Descriptor:Putative N-acetylmannosamine-6-phosphate 2-epimerase, N-acetylmannosamine-6-phosphate, DI(HYDROXYETHYL)ETHER, ...
Authors:Manjunath, L., Guntupalli, S.
Deposit date:2018-03-21
Release date:2018-09-19
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae
Acta Crystallogr F Struct Biol Commun, 74, 2018
5ZJP
  • Download 5zjp
  • View 5zjp
Molmil generated image of 5zjp
STRUCTURE OF N-ACETYLMANNOSAMINE-6-PHOSPHATE-2-EPIMERASE FROM VIBRIO CHOLERAE WITH N-ACETYLGLUCOSAMINE-6-PHOSPHATE
Descriptor:Putative N-acetylmannosamine-6-phosphate 2-epimerase, N-acetyl-D-glucosamine-6-phosphate, TRIETHYLENE GLYCOL, ...
Authors:Manjunath, L., Guntupalli, S.R.
Deposit date:2018-03-21
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae
Acta Crystallogr F Struct Biol Commun, 74, 2018
5ZKN
  • Download 5zkn
  • View 5zkn
Molmil generated image of 5zkn
STRUCTURE OF N-ACETYLMANNOSAMINE-6-PHOSPHATE 2-EPIMERASE FROM FUSOBACTERIUM NUCLEATUM
Descriptor:Putative N-acetylmannosamine-6-phosphate 2-epimerase, CHLORIDE ION
Authors:Manjunath, L.
Deposit date:2018-03-24
Release date:2018-09-19
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae
Acta Crystallogr F Struct Biol Commun, 74, 2018