1R7S | | PUTIDAREDOXIN (FE2S2 FERREDOXIN), C73G MUTANT | | Descriptor: | Putidaredoxin, FE2/S2 (INORGANIC) CLUSTER | | Authors: | Smith, N., Mayhew, M., Kelly, H., Robinson, H., Heroux, A., Holden, M.J., Gallagher, D.T. | | Deposit date: | 2003-10-22 | | Release date: | 2004-04-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structure of C73G putidaredoxin from Pseudomonas putida.
Acta Crystallogr.,Sect.D, 60, 2004
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1JD3 | | CHORISMATE LYASE G90A MUTANT WITH BOUND PRODUCT | | Descriptor: | chorismate lyase, P-HYDROXYBENZOIC ACID | | Authors: | Mayhew, M., Smith, N., Holden, M.J., Gallagher, D.T. | | Deposit date: | 2001-06-12 | | Release date: | 2001-06-20 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structural analysis of ligand binding and catalysis in chorismate lyase.
Arch.Biochem.Biophys., 445, 2006
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1XLR | | CHORISMATE LYASE WITH INHIBITOR VANILLATE | | Descriptor: | Chorismate--pyruvate lyase, 4-HYDROXY-3-METHOXYBENZOATE | | Authors: | Gallagher, D.T., Smith, N. | | Deposit date: | 2004-09-30 | | Release date: | 2004-11-09 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Structural analysis of ligand binding and catalysis in chorismate lyase.
Arch.Biochem.Biophys., 445, 2006
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2Y37 | | THE DISCOVERY OF NOVEL, POTENT AND HIGHLY SELECTIVE INHIBITORS OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) | | Descriptor: | NITRIC OXIDE SYNTHASE, INDUCIBLE, SULFATE ION, ... | | Authors: | Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T.N., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V. | | Deposit date: | 2010-12-19 | | Release date: | 2011-04-13 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos).
Bioorg.Med.Chem.Lett., 21, 2011
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4UX6 | | THE DISCOVERY OF NOVEL, POTENT AND HIGHLY SELECTIVE INHIBITORS OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) | | Descriptor: | NITRIC OXIDE SYNTHASE, INDUCIBLE, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V. | | Deposit date: | 2014-08-19 | | Release date: | 2014-10-08 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos).
Bioorg.Med.Chem.Lett., 21, 2011
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2WHJ | | UNDERSTANDING HOW DIVERSE MANNANASES RECOGNISE HETEROGENEOUS SUBSTRATES | | Descriptor: | BETA-MANNANASE, GLYCEROL, ACETATE ION, ... | | Authors: | Tailford, L.E., Ducros, V.M.A., Flint, J.E., Roberts, S.M., Morland, C., Zechel, D.L., Smith, N., Bjornvad, M.E., Borchert, T.V., Wilson, K.S., Davies, G.J., Gilbert, H.J. | | Deposit date: | 2009-05-05 | | Release date: | 2009-05-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
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2WHL | | UNDERSTANDING HOW DIVERSE MANNANASES RECOGNISE HETEROGENEOUS SUBSTRATES | | Descriptor: | BETA-MANNANASE, ACETATE ION, ALPHA-D-MANNOSE, ... | | Authors: | Tailford, L.E., Ducros, V.M.A., Flint, J.E., Roberts, S.M., Morland, C., Zechel, D.L., Smith, N., Bjornvad, M.E., Borchert, T.V., Wilson, K.S., Davies, G.J., Gilbert, H.J. | | Deposit date: | 2009-05-05 | | Release date: | 2009-05-26 | | Last modified: | 2012-11-28 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
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2WZS | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT3990 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 IN COMPLEX WITH MANNOIMIDAZOLE | | Descriptor: | PUTATIVE ALPHA-1,2-MANNOSIDASE, CALCIUM ION, (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, ... | | Authors: | Zhu, Y., Suits, M.D.L., Thompson, A., Chavan, S., Dinev, Z., Dumon, C., Smith, N., Moremen, K.W., Xiang, Y., Siriwardena, A., Williams, S.J., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-12-02 | | Release date: | 2009-12-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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1TT8 | | CHORISMATE LYASE WITH PRODUCT, 1.0 A RESOLUTION | | Descriptor: | Chorismate-pyruvate lyase, P-HYDROXYBENZOIC ACID | | Authors: | Gallagher, D.T., Mayhew, M., Holden, M.J., Vilker, V., Howard, A. | | Deposit date: | 2004-06-22 | | Release date: | 2004-12-28 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Structural analysis of ligand binding and catalysis in chorismate lyase.
Arch.Biochem.Biophys., 445, 2006
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2VOT | | STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES | | Descriptor: | BETA-MANNOSIDASE, (5R,6R,7S,8R)-6,7,8-trihydroxy-5-(hydroxymethyl)-2-[(phenylamino)methyl]-5,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyridin-4-ium, 1,2-ETHANEDIOL, ... | | Authors: | Tailford, L.N., Offen, W.A., Smith, N., Dumon, C., Moreland, C., Gratien, J., Heck, M.-P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2008-02-20 | | Release date: | 2008-04-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
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1OMO | | ALANINE DEHYDROGENASE DIMER W/BOUND NAD (ARCHAEAL) | | Descriptor: | alanine dehydrogenase, SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Gallagher, D.T., Smith, N.N., Holden, M.J., Schroeder, I., Monbouquette, H.G. | | Deposit date: | 2003-02-25 | | Release date: | 2004-07-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.
J.Mol.Biol., 342, 2004
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2CCL | | THE S45A, T46A MUTANT OF THE TYPE I COHESIN-DOCKERIN COMPLEX FROM THE CELLULOSOME OF CLOSTRIDIUM THERMOCELLUM | | Descriptor: | CELLULOSOMAL SCAFFOLDING PROTEIN A, ENDO-1,4-BETA-XYLANASE Y, PHOSPHATE ION, ... | | Authors: | Carvalho, A.L., Dias, F.M.V., Prates, J.A.M., Ferreira, L.M.A., Gilbert, H.J., Davies, G.J., Romao, M.J., Fontes, C.M.G.A. | | Deposit date: | 2006-01-16 | | Release date: | 2007-02-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Evidence for a Dual Binding Mode of Dockerin Modules to Cohesins.
Proc.Natl.Acad.Sci.USA, 104, 2007
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2WHK | | STRUCTURE OF BACILLUS SUBTILIS MANNANASE MAN26 | | Descriptor: | MANNAN ENDO-1,4-BETA-MANNOSIDASE, GLYCEROL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Ducros, V.M.A., Davies, G.J. | | Deposit date: | 2009-05-05 | | Release date: | 2009-05-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
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2WHM | | CELLVIBRIO JAPONICUS MAN26A E121A AND E320G DOUBLE MUTANT IN COMPLEX WITH MANNOBIOSE | | Descriptor: | ENDO-1,4-BETA MANNANASE, MAN26A, ZINC ION, ... | | Authors: | Durcos, V.M.A., Davies, G.J., Flint, J.E., Gilbert, H.J. | | Deposit date: | 2009-05-05 | | Release date: | 2009-05-26 | | Last modified: | 2015-03-18 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
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2WVX | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT3990 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 | | Descriptor: | PUTATIVE ALPHA-1,2-MANNOSIDASE, CALCIUM ION, GLYCEROL | | Authors: | Suits, M.D.L., Zhu, Y., Thompson, A., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-10-21 | | Release date: | 2009-11-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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2WVY | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT2199 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 | | Descriptor: | ALPHA-1,2-MANNOSIDASE | | Authors: | Suits, M.D.L., Zhu, Y., Thompson, A., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-10-21 | | Release date: | 2009-11-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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2WVZ | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT3990 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 | | Descriptor: | PUTATIVE ALPHA-1,2-MANNOSIDASE, CALCIUM ION, KIFUNENSINE, ... | | Authors: | Suits, M.D.L., Zhu, Y., Thompson, A., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-10-21 | | Release date: | 2009-12-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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2WW0 | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT3990 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 | | Descriptor: | PUTATIVE ALPHA-1,2-MANNOSIDASE, CALCIUM ION, 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, ... | | Authors: | Suits, M.D.L., Thompson, A., Zhu, Y., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-10-21 | | Release date: | 2009-12-29 | | Last modified: | 2013-05-22 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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2WW1 | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT3990 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 IN COMPLEX WITH THIOMANNOBIOSIDE | | Descriptor: | PUTATIVE ALPHA-1,2-MANNOSIDASE, METHYL-2-S-(ALPHA-D-MANNOPYRANOSYL)-2-THIO-ALPHA-D-MANNOPYRANOSIDE | | Authors: | Suits, M.D.L., Zhu, Y., Thompson, A., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-10-21 | | Release date: | 2009-12-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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2WW2 | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT2199 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 | | Descriptor: | ALPHA-1,2-MANNOSIDASE, (4S)-2-METHYL-2,4-PENTANEDIOL, SODIUM ION, ... | | Authors: | Suits, M.D.L., Zhu, Y., Thompson, A., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-10-21 | | Release date: | 2009-12-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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2WW3 | | STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT3990 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 IN COMPLEX WITH THIOMANNOBIOSIDE | | Descriptor: | PUTATIVE ALPHA-1,2-MANNOSIDASE, CALCIUM ION, METHYL-2-S-(ALPHA-D-MANNOPYRANOSYL)-2-THIO-ALPHA-D-MANNOPYRANOSIDE, ... | | Authors: | Suits, M.D.L., Zhu, Y., Thompson, A.J., Gilbert, H.J., Davies, G.J. | | Deposit date: | 2009-10-21 | | Release date: | 2010-01-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mechanistic Insights Into a Ca(2+)-Dependent Family of Alpha-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
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3B9S | | MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) COMPLEXED WITH INHIBITOR, 4-IPP. | | Descriptor: | Macrophage Migration Inhibitory Factor, GLYCEROL, 4-phenylpyrimidine, ... | | Authors: | Zierow, S., Crichlow, G., Lolis, E. | | Deposit date: | 2007-11-06 | | Release date: | 2008-09-23 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
Cancer Res., 68, 2008
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3D0S | |
4C7T | | FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH A DIARYLAMINO- 1,3,5-TRIAZINE INHIBITOR | | Descriptor: | FOCAL ADHESION KINASE 1, N-methyl-2-[[4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]benzamide, SULFATE ION | | Authors: | Le Coq, J., Lietha, D. | | Deposit date: | 2013-09-25 | | Release date: | 2014-04-02 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Inhibition of Both Focal Adhesion Kinase and Fibroblast Growth Factor Receptor 2 Pathways Induces Anti-Tumor and Anti-Angiogenic Activities.
Cancer Lett., 348, 2014
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4X2Q | | CRYSTAL STRUCTURE OF HUMAN ALDEHYDE DEHYDROGENASE, ALDH1A2 | | Descriptor: | Retinal dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Stenkamp, R.E., Le Trong, I., Amory, J.K., Paik, J., Goldstein, A.S. | | Deposit date: | 2014-11-26 | | Release date: | 2015-12-02 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Synthesis and In Vitro Testing of Bisdichloroacetyldiamine Analogs for Use as a Reversible Male Contraceptive
To Be Published
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