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5JFS
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-00593174
Descriptor:High affinity nerve growth factor receptor, N-{4-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-N'-(2,4-difluorophenyl)urea
Authors:Jayasankar, J., Brown, D., Skerratt, S., Kurumbail, R.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFV
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-05206283
Descriptor:High affinity nerve growth factor receptor, N-{5-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide
Authors:Jayasankar, J., Kurumbail, R., Brown, D., Skerratt, S.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFW
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-05247452
Descriptor:High affinity nerve growth factor receptor, 2-(4-cyanophenyl)-N-{5-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide
Authors:Jayasankar, J., Kurumbail, R., Skerratt, S., Brown, D.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFX
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-06273340
Descriptor:High affinity nerve growth factor receptor, N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide
Authors:Jayasankar, J., Kurumbail, R., Skerratt, S., Brown, D.
Deposit date:2016-04-19
Release date:2017-03-01
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016