Author results

4BQG
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STRUCTURE OF HSP90 WITH AN INHIBITOR BOUND
Descriptor:HSP90AA1 PROTEIN, 5-(3,4-dichloro-phenoxy)-benzene-1,3-diol
Authors:Casale, E., Brasca, M.G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Ceccarelli, W., Colombo, N., DePonti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E.R., Ferguson, R.D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Fogliatto, G.
Deposit date:2013-05-30
Release date:2013-10-23
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of Nms-E973 as Novel, Selective and Potent Inhibitor of Heat Shock Protein 90 (Hsp90).
Bioorg.Med.Chem., 21, 2013
4BQJ
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STRUCTURE OF HSP90 WITH AN INHIBITOR BOUND
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-ethyl-1,2-oxazole-3-carboxamide
Authors:Casale, E., Brasca, M.G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Ceccarelli, W., Colombo, N., DePonti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E.R., Ferguson, R.D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Fogliatto, G.
Deposit date:2013-05-30
Release date:2013-10-23
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Nms-E973 as Novel, Selective and Potent Inhibitor of Heat Shock Protein 90 (Hsp90).
Bioorg.Med.Chem., 21, 2013
4CWF
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-propyl[1,2,4]triazolo[1,5-c]quinazolin-2-amine
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-02
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4CWN
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(3,5-dimethoxybenzyl)[1,2,4]triazolo[1,5-c]quinazolin-2-amine
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-03
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4CWO
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(2-amino-[1,2,4]triazolo[1,5-c]quinazolin-5-ylmethyl)-benzene-1,3-diol
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-03
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4CWP
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazolin-2-amine
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-03
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4CWQ
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 2-amino-5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazoline-8-sulfonamide
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-03
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4CWR
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(1,3-benzodioxol-5-ylmethyl)-10-fluoro[1,2,4]triazolo[1,5-c]quinazolin-2-amine
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-03
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4CWS
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 2-{[2-amino-5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino}ethanol
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-03
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4CWT
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HUMAN HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZOLOQUINAZOLINE INHIBITOR
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 2-{[(2Z)-5-(1,3-benzodioxol-5-ylmethyl)-8-fluoro-2-imino-2,3-dihydro[1,2,4]triazolo[1,5-c]quinazolin-10-yl]amino}ethanol
Authors:Casale, E., Amboldi, N., Brasca, G., Caronni, D., Colombo, N., Dalvit, C., Felder, E.R., Fogliatto, G., Isacchi, A., Mantegani, S., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Casuscelli, F.
Deposit date:2014-04-03
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22, 2014