Author results

5CLM
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1,4-OXAZINE BACE1 INHIBITORS
Descriptor:Beta-secretase 1, N-{3-[(3R)-5-amino-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide, IODIDE ION, ...
Authors:Rombouts, F., Tresadern, G., Delgado, O., Martinez Lamenca, C., Van Gool, M., Garcia-Molina, A., Alonso De Diego, S., Oehlrich, D., Prokopcova, H., Alonso, J.M., Austin, N., Borghys, H., Van Brandt, S., Surkyn, M., De Cleyn, M., Vos, A., Alexander, R., MacDonald, G., Moechars, D., Trabanco, A., Gijsen, H.
Deposit date:2015-07-16
Release date:2015-09-30
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:1,4-Oxazine beta-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.
J.Med.Chem., 58, 2015
2X7C
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-ENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7D
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-DIMETHYLENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7E
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-FLUORASTROL
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010