Author results

4CRH
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CRYSTAL STRUCTURE OF THE BTB-T1 DOMAIN OF HUMAN SHKBP1
Descriptor:SH3KBP1-BINDING PROTEIN 1
Authors:Pinkas, D.M., Solcan, N., Krojer, T., Goubin, S., Williams, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-02-26
Release date:2014-03-12
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
4UIJ
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF KCTD13
Descriptor:BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 1, CHLORIDE ION
Authors:Pinkas, D.M., Sanvitale, C.E., Sorell, F.J., Solcan, N., Goubin, S., Canning, P., Williams, E., Chaikuad, A., Dixon Clarke, S.E., Tallant, C., Fonseca, M., Chalk, R., Doutch, J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-03-30
Release date:2015-11-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
4URJ
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CRYSTAL STRUCTURE OF HUMAN BJ-TSA-9
Descriptor:PROTEIN FAM83A, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Sanvitale, C., Wang, D., Krojer, T., Kopec, J., Chaikuad, A., Dixon Clarke, S., Berridge, G., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Bullock, A.
Deposit date:2014-06-30
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Bj-Tsa-9
To be Published
4UUC
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CRYSTAL STRUCTURE OF HUMAN ASB11 ANKYRIN REPEAT DOMAIN
Descriptor:ANKYRIN REPEAT AND SOCS BOX PROTEIN 11
Authors:Pinkas, D.M., Sanvitale, C., Kragh Nielsen, T., Guo, K., Sorrell, F., Berridge, G., Ayinampudi, V., Wang, D., Newman, J.A., Tallant, C., Chaikuad, A., Canning, P., Kopec, J., Krojer, T., Vollmar, M., Allerston, C.K., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Bullock, A.
Deposit date:2014-07-25
Release date:2014-08-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Human Asb11 Ankyrin Repeat Domain
To be Published
4UYI
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN SLX4 (BTBD12)
Descriptor:STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4
Authors:Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-09-01
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure of the Btb Domain of Human Slx4 (Btbd12)
To be Published
5A15
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN KCTD16
Descriptor:BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD16
Authors:Pinkas, D.M., Sanvitale, C.E., Solcan, N., Goubin, S., Canning, P., Dixon Clarke, S.E., Talon, R., Wiggers, H.J., Fitzpatrick, F., Tallant, C., Kopec, J., Chalk, R., Doutch, J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-04-28
Release date:2015-11-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
5A6R
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN KCTD17
Descriptor:BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD17
Authors:Pinkas, D.M., Sorrell, F., Sanvitale, C.E., Goubin, S., Williams, E., Newman, J.A., Pearce, N.M., Neshich, I., Pike, A.C.W., MacKenzie, A., Quigley, A., Faust, B., Carpenter, E.P., Tallant, C., Kopec, J., Chalk, R., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
5FTA
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CRYSTAL STRUCTURE OF THE N-TERMINAL BTB DOMAIN OF HUMAN KCTD10
Descriptor:BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 3, MERCURY (II) ION
Authors:Pinkas, D.M., Sanvitale, C.E., Solcan, N., Goubin, S., Tallant, C., Newman, J.A., Kopec, J., Fitzpatrick, F., Talon, R., Collins, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2016-01-12
Release date:2016-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
5G3Q
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CRYSTAL STRUCTURE OF A HYPOTHETICAL DOMAIN IN WNK1
Descriptor:WNK1
Authors:Pinkas, D.M., Bufton, J.C., Sanvitale, C.E., Bartual, S.G., Adamson, R.J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2016-04-29
Release date:2017-05-31
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.613 Å)
Cite:Crystal Structure of a Hypothetical Domain in Wnk1
To be Published
5LZK
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STRUCTURE OF THE DOMAIN OF UNKNOWN FUNCTION DUF1669 FROM HUMAN FAM83B
Descriptor:Protein FAM83B, IODIDE ION, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Bufton, J.C., Williams, E.P., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2016-09-29
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.575 Å)
Cite:Structure of the domain of unknown function DUF1669 from human FAM83B
To Be Published
5O1V
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CRYSTAL STRUCTURE OF WNK3 KINASE DOMAIN IN A MONOPHOSPHORYLATED APO STATE (A-LOOP SWAPPED)
Descriptor:Serine/threonine-protein kinase WNK3, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Bufton, J.C., Kupinska, K., Wang, D., Fairhead, M., Kopec, J., Sethi, R., Dixon-Clarke, S.E., Chalk, R., Berridge, G., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2017-05-19
Release date:2017-06-28
Method:X-RAY DIFFRACTION (1.723 Å)
Cite:Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (A-loop swapped)
To Be Published
5O21
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CRYSTAL STRUCTURE OF WNK3 KINASE DOMAIN IN A MONOPHOSPHORYLATED STATE WITH CHLORIDE BOUND IN THE ACTIVE SITE
Descriptor:Serine/threonine-protein kinase WNK3, CHLORIDE ION, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Bufton, J.C., Kupinska, K., Wang, D., Fairhead, M., Chalk, R., Berridge, G., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2017-05-19
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structure of WNK3 kinase domain in a monophosphorylated state with chloride bound in the active site
To Be Published
5O23
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CRYSTAL STRUCTURE OF WNK3 KINASE DOMAIN IN A MONOPHOSPHORYLATED APO STATE
Descriptor:Serine/threonine-protein kinase WNK3, SULFATE ION, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Bufton, J.C., Kupinska, K., Wang, D., Sethi, R., Newman, J.A., Chalk, R., Berridge, G., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2017-05-19
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of WNK3 kinase domain in a monophosphorylated apo state
To Be Published
5O26
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CRYSTAL STRUCTURE OF WNK3 KINASE DOMAIN IN A DIPHOSPHORYLATED STATE AND IN COMPLEX WITH AMP-PNP/MG2+
Descriptor:Serine/threonine-protein kinase WNK3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Pinkas, D.M., Bufton, J.C., Newman, J.A., Kopec, J., Borkowska, O., Chalk, R., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2017-05-19
Release date:2017-06-28
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.379 Å)
Cite:Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+
To Be Published
5O2B
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CRYSTAL STRUCTURE OF WNK3 KINASE DOMAIN IN A DIPHOSPHORYLATED STATE AND IN A COMPLEX WITH THE INHIBITOR PP-121
Descriptor:Serine/threonine-protein kinase WNK3, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SODIUM ION
Authors:Pinkas, D.M., Bufton, J.C., Newman, J.A., Borkowska, O., Chalk, R., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2017-05-19
Release date:2017-06-28
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.038 Å)
Cite:Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121
To Be Published
5QHI
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000271A
Descriptor:Protein FAM83B, IODIDE ION, 1,2-ETHANEDIOL, ...
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHJ
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000709A
Descriptor:Protein FAM83B, IODIDE ION, 1,2-ETHANEDIOL, ...
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHK
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000010A
Descriptor:Protein FAM83B, IODIDE ION, 1,2-ETHANEDIOL, ...
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHL
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000551A
Descriptor:Protein FAM83B, IODIDE ION, 1,2-ETHANEDIOL, ...
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHM
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH OX-145
Descriptor:Protein FAM83B, 1,2-ETHANEDIOL, 1-methyl-3-oxidanyl-pyridine-2-thione
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHN
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000622A
Descriptor:Protein FAM83B, 1,2-ETHANEDIOL, methyl (2~{S},4~{R})-1-(furan-2-ylcarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylate
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHO
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000010A
Descriptor:Protein FAM83B, 1,2-ETHANEDIOL, di(piperidin-1-yl)methanone
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHP
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000554A
Descriptor:Protein FAM83B, 1,2-ETHANEDIOL, 5-methoxy-2-(1~{H}-pyrazol-3-yl)phenol
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHQ
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000574A
Descriptor:Protein FAM83B, 1,2-ETHANEDIOL, 1-[(4-fluorophenyl)methyl]benzimidazole
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
5QHR
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PANDDA ANALYSIS GROUP DEPOSITION OF MODELS WITH MODELLED EVENTS (E.G. BOUND LIGANDS) -- CRYSTAL STRUCTURE OF HUMAN FAM83B IN COMPLEX WITH FMOPL000635A
Descriptor:Protein FAM83B, 1,2-ETHANEDIOL, N-(3-fluorophenyl)-5-methyl-1,3,4-thiadiazol-2-amine
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Talon, R., Krojer, T., Douangamath, A., Collins, P., Zhang, R., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Bullock, A.N.
Deposit date:2018-05-18
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)
To Be Published
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