Search by PDB author

Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide
Descriptor:	2-[(trans-4-hydroxycyclohexyl)amino]-4-[5-(4-phenyl-1H-imidazol-1-yl)isoquinolin-1-yl]benzamide, Heat shock protein HSP 90-alpha
Authors:	Chong, K.T, Yamashita, S, Oshiumi, H, Uno, T, Kitade, M.
Deposit date:	2014-01-23
Release date:	2015-02-25
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Evolution of highly selective Hsp90 / inhibitors by structure and thermodynamics guided design To be Published

Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide
Descriptor:	3-methyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide, Heat shock protein HSP 90-alpha
Authors:	Uno, T, Chong, K.T, Suzuki, T.
Deposit date:	2018-04-23
Release date:	2019-01-02
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor. J. Med. Chem., 62, 2019